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LPAR1 lysophosphatidic acid receptor 1 [ Bos taurus (domestic cattle) ]

Gene ID: 281136, updated on 1-Jan-2025

Summary

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Official Symbol
LPAR1provided by VGNC
Official Full Name
lysophosphatidic acid receptor 1provided by VGNC
Primary source
VGNC:VGNC:30955
See related
Ensembl:ENSBTAG00000009654
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
EDG2
Orthologs
human mouse all
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Genomic context

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See LPAR1 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (100350056..100518672, complement)

Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 Neighboring gene uncharacterized LOC132346007 Neighboring gene muscle associated receptor tyrosine kinase Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene small nucleolar RNA SNORA71 Neighboring gene uncharacterized LOC112447838 Neighboring gene microRNA mir-2285n-5 Neighboring gene uncharacterized LOC112447938

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Lysophosphatidic acid stimulates prostaglandin E2 production in cultured stromal endometrial cells through LPA1 receptor. Woclawek-Potocka I, et al. Exp Biol Med (Maywood), 2009 Aug. PMID 19491366
  2. Which bovine endometrial cells are the source of and target for lysophosphatidic acid? Boruszewska D, et al. Reprod Biol, 2013 Mar. PMID 23522079
  3. Cloning, characterization, and chromosomal localization of rec1.3, a member of the G-protein-coupled receptor family highly expressed in brain. Macrae AD, et al. Brain Res Mol Brain Res, 1996 Dec. PMID 9013780
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. expression is lower in epithelial cells than in stromal cells of the endometrium
    Title: Which bovine endometrial cells are the source of and target for lysophosphatidic acid?
  2. Lysophosphatidic acid stimulates PGE(2) production, cell viability, and intracellular calcium ion mobilization in cultured stromal endometrial cells via Ki16425-sensitive LPA1 receptors.
    Title: Lysophosphatidic acid stimulates prostaglandin E2 production in cultured stromal endometrial cells through LPA1 receptor.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables lysophosphatidic acid receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neurogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
lysophosphatidic acid receptor 1
Names
LPA receptor 1
LPA-1
endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2
lysophosphatidic acid receptor Edg-2
rec1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174047.2 → NP_776472.1  lysophosphatidic acid receptor 1

    See identical proteins and their annotated locations for NP_776472.1

    Status: PROVISIONAL

    Source sequence(s)
    U48236
    UniProtKB/Swiss-Prot
    Q28031
    UniProtKB/TrEMBL
    F1MRZ9
    Conserved Domains (1) summary
    pfam00001
    Location:67 → 311
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    100350056..100518672 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010808241.4 → XP_010806543.1  lysophosphatidic acid receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_010806543.1

    UniProtKB/TrEMBL
    A0A3Q1M9C6, F1MRZ9
    Related
    ENSBTAP00000070704.1, ENSBTAT00000085678.2
    Conserved Domains (1) summary
    cd15344
    Location:50 → 322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_005210511.5 → XP_005210568.1  lysophosphatidic acid receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_005210568.1

    UniProtKB/TrEMBL
    A0A3Q1M9C6, F1MRZ9
    Conserved Domains (1) summary
    cd15344
    Location:50 → 322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_059888945.1 → XP_059744928.1  lysophosphatidic acid receptor 1 isoform X1

    UniProtKB/TrEMBL
    A0A3Q1M9C6, F1MRZ9

  4. XM_005210512.5 → XP_005210569.1  lysophosphatidic acid receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_005210569.1

    UniProtKB/TrEMBL
    A0A3Q1M9C6, F1MRZ9
    Conserved Domains (1) summary
    cd15344
    Location:50 → 322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors

  5. XM_005210513.5 → XP_005210570.1  lysophosphatidic acid receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_005210570.1

    UniProtKB/TrEMBL
    A0A3Q1M9C6, F1MRZ9
    Conserved Domains (1) summary
    cd15344
    Location:50 → 322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors

  6. XM_024995437.2 → XP_024851205.1  lysophosphatidic acid receptor 1 isoform X1

    UniProtKB/TrEMBL
    A0A3Q1M9C6, F1MRZ9
    Conserved Domains (1) summary
    cd15344
    Location:50 → 322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q28031.1 GenPept UniProtKB/Swiss-Prot:Q28031

Gene LinkOut

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