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FLNA filamin A [ Bos taurus (domestic cattle) ]

Gene ID: 281165, updated on 27-Dec-2024

Summary

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Official Symbol
FLNAprovided by VGNC
Official Full Name
filamin Aprovided by VGNC
Primary source
VGNC:VGNC:29033
See related
BGD:BT10873; Ensembl:ENSBTAG00000011190
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See FLNA in Genome Data Viewer
Location:
chromosome: X
Exon count:
48
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) X NC_037357.1 (37397606..37422676, complement)

Chromosome X - NC_037357.1Genomic Context describing neighboring genes Neighboring gene small ribosomal subunit protein eS27-like Neighboring gene testis expressed 28 Neighboring gene transketolase like 1 Neighboring gene uncharacterized LOC101904339 Neighboring gene emerin

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Filamin-A binds to the carboxyl-terminal tail of the calcium-sensing receptor, an interaction that participates in CaR-mediated activation of mitogen-activated protein kinase. Hjälm G, et al. J Biol Chem, 2001 Sep 14. PMID 11390380
  2. The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7. Enz R. FEBS Lett, 2002 Mar 13. PMID 11943148
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
filamin-A
Names
filamin A, alpha (actin binding protein 280)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206514.1 → NP_001193443.1  filamin-A

    See identical proteins and their annotated locations for NP_001193443.1

    Status: VALIDATED

    Source sequence(s)
    DT809165, DV817603, DV883744, EE335622, EE373698, EH173403, EH208656, EH208927, EV745062, NKLS02000030
    UniProtKB/TrEMBL
    A0A3Q1LMA3, F1N169
    Related
    ENSBTAP00000030179.5, ENSBTAT00000030194.6
    Conserved Domains (4) summary
    smart00033
    Location:172 → 264
    CH; Calponin homology domain
    smart00557
    Location:2047 → 2136
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00014
    Location:44 → 148
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00630
    Location:1445 → 1536
    Filamin; Filamin/ABP280 repeat

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037357.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    37397606..37422676 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024987749.2 → XP_024843517.1  filamin-A isoform X1

    UniProtKB/TrEMBL
    A0A3Q1LMA3, A0A3Q1M057
    Related
    ENSBTAP00000061341.2, ENSBTAT00000071764.2
    Conserved Domains (2) summary
    smart00557
    Location:2039 → 2128
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5069
    Location:41 → 267
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

  2. XM_059883272.1 → XP_059739255.1  filamin-A isoform X3

    UniProtKB/TrEMBL
    A0A3Q1LMA3

  3. XM_059883271.1 → XP_059739254.1  filamin-A isoform X2

    UniProtKB/TrEMBL
    A0A3Q1LMA3

  4. XM_024987750.2 → XP_024843518.1  filamin-A isoform X1

    UniProtKB/TrEMBL
    A0A3Q1LMA3, A0A3Q1M057
    Conserved Domains (2) summary
    smart00557
    Location:2039 → 2128
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5069
    Location:41 → 267
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
Nucleotide Protein Strain
Heading Accession and Version

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