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HPRT1 hypoxanthine phosphoribosyltransferase 1 [ Bos taurus (domestic cattle) ]

Gene ID: 281229, updated on 1-Jan-2025

Summary

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Gene symbol
HPRT1
Gene description
hypoxanthine phosphoribosyltransferase 1
See related
BGD:BT23983; Ensembl:ENSBTAG00000014685
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
HPRT; HGPRT
Orthologs
human mouse all
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Genomic context

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See HPRT1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) X NC_037357.1 (18177361..18208571)

Chromosome X - NC_037357.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107131993 Neighboring gene coiled-coil domain containing 160 Neighboring gene U6 spliceosomal RNA Neighboring gene PHD finger protein 6 Neighboring gene microRNA mir-450a-1 Neighboring gene microRNA mir-450b

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Clarifications on breakpoints in HSAX and BTAX by comparative mapping of F9, HPRT, and XIST in cattle. Goldammer T, et al. Cytogenet Genome Res, 2003. PMID 14571135
  2. Forms of selenium in vitamin-mineral mixes differentially affect serum alkaline phosphatase activity, and serum albumin and blood urea nitrogen concentrations, of steers grazing endophyte-infected tall fescue. Jia Y, et al. J Anim Sci, 2019 May 30. PMID 30957833, Free PMC Article
  3. Sex-chromosome linked gene expression in in-vitro produced bovine embryos. Peippo J, et al. Mol Hum Reprod, 2002 Oct. PMID 12356942
  4. Selection of reference genes for quantitative real-time PCR in bovine preimplantation embryos. Goossens K, et al. BMC Dev Biol, 2005 Dec 3. PMID 16324220, Free PMC Article
  5. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. levels of G6PD and HPRT RNA were higher in female morulae and blastocysts than in males
    Title: Sex-chromosome linked gene expression in in-vitro produced bovine embryos.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC128800

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables hypoxanthine phosphoribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in GMP salvage IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in IMP salvage IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in guanine salvage IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hypoxanthine metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in purine ribonucleoside salvage IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
hypoxanthine-guanine phosphoribosyltransferase
Names
HGPRTase
hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome)
NP_001029207.1
XP_059739256.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034035.2 → NP_001029207.1  hypoxanthine-guanine phosphoribosyltransferase

    See identical proteins and their annotated locations for NP_001029207.1

    Status: PROVISIONAL

    Source sequence(s)
    BC103248
    UniProtKB/Swiss-Prot
    Q3SZ18
    UniProtKB/TrEMBL
    Q1JP91
    Related
    ENSBTAP00000088561.1, ENSBTAT00000111869.1
    Conserved Domains (1) summary
    cl00309
    Location:3 → 218
    PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037357.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    18177361..18208571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059883273.1 → XP_059739256.1  hypoxanthine-guanine phosphoribosyltransferase isoform X1

    UniProtKB/TrEMBL
    A0AAA9S2N2, Q1JP91
    Related
    ENSBTAP00000079306.1, ENSBTAT00000109498.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3SZ18.3 GenPept UniProtKB/Swiss-Prot:Q3SZ18

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.