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LDHA lactate dehydrogenase A [ Bos taurus (domestic cattle) ]

Gene ID: 281274, updated on 1-Jan-2025

Summary

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Gene symbol
LDHA
Gene description
lactate dehydrogenase A
See related
BGD:BT10370; Ensembl:ENSBTAG00000008683
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
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Genomic context

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See LDHA in Genome Data Viewer
Location:
chromosome: 29
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 29 NC_037356.1 (26290889..26302946, complement)

Chromosome 29 - NC_037356.1Genomic Context describing neighboring genes Neighboring gene tumor susceptibility 101 Neighboring gene WW domain-binding protein 2-like Neighboring gene lactate dehydrogenase C Neighboring gene uncharacterized LOC132344183 Neighboring gene uncharacterized LOC104976244 Neighboring gene uncharacterized LOC132344184 Neighboring gene general transcription factor IIH subunit 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Primary structure of bovine lactate dehydrogenase-A isozyme and its synthesis in Escherichia coli. Ishiguro N, et al. Gene, 1990 Jul 16. PMID 2210387
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables L-lactate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in lactate metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in pyruvate metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
L-lactate dehydrogenase A chain
Names
LDH muscle subunit
LDH-A
LDH-M
NP_776524.1
XP_005226796.1
XP_010819169.1
XP_059738736.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174099.2 → NP_776524.1  L-lactate dehydrogenase A chain

    See identical proteins and their annotated locations for NP_776524.1

    Status: PROVISIONAL

    Source sequence(s)
    D90143
    UniProtKB/Swiss-Prot
    A6H7E0, P19858
    UniProtKB/TrEMBL
    A0A3Q1LY19
    Conserved Domains (1) summary
    cd05293
    Location:19 → 329
    LDH_1; A subgroup of L-lactate dehydrogenases

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037356.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    26290889..26302946 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010820867.3 → XP_010819169.1  L-lactate dehydrogenase A chain isoform X1

    UniProtKB/TrEMBL
    A0AAA9T2Y5
    Related
    ENSBTAP00000093153.1, ENSBTAT00000115709.1
    Conserved Domains (2) summary
    cd05293
    Location:76 → 386
    LDH_1; A subgroup of L-lactate dehydrogenases
    TIGR01771
    Location:82 → 381
    L-LDH-NAD; L-lactate dehydrogenase

  2. XM_005226739.4 → XP_005226796.1  L-lactate dehydrogenase A chain isoform X3

    See identical proteins and their annotated locations for XP_005226796.1

    UniProtKB/Swiss-Prot
    A6H7E0, P19858
    UniProtKB/TrEMBL
    A0A3Q1LY19
    Related
    ENSBTAP00000047729.3, ENSBTAT00000056276.4
    Conserved Domains (1) summary
    cd05293
    Location:19 → 329
    LDH_1; A subgroup of L-lactate dehydrogenases

  3. XM_059882753.1 → XP_059738736.1  L-lactate dehydrogenase A chain isoform X2

    UniProtKB/TrEMBL
    A0A3Q1LY19, A0AAF6YSZ5
    Related
    ENSBTAP00000011447.4, ENSBTAT00000011447.5
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P19858.2 GenPept UniProtKB/Swiss-Prot:P19858

Gene LinkOut

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