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ADGRL2 adhesion G protein-coupled receptor L2 [ Bos taurus (domestic cattle) ]

Gene ID: 281278, updated on 1-Jan-2025

Summary

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Official Symbol
ADGRL2provided by VGNC
Official Full Name
adhesion G protein-coupled receptor L2provided by VGNC
Primary source
VGNC:VGNC:53846
See related
Ensembl:ENSBTAG00000012305
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
LEC2; LPHN2
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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See ADGRL2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (62437260..63147752, complement)

Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1A pseudogene Neighboring gene transfer RNA serine (anticodon GGA) Neighboring gene ATP synthase subunit epsilon, mitochondrial-like Neighboring gene transfer RNA cysteine (anticodon ACA)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. The latrophilin family: multiply spliced G protein-coupled receptors with differential tissue distribution. Matsushita H, et al. FEBS Lett, 1999 Jan 29. PMID 10025961
  2. Alpha-latrotoxin receptor, latrophilin, is a novel member of the secretin family of G protein-coupled receptors. Lelianova VG, et al. J Biol Chem, 1997 Aug 22. PMID 9261169
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
adhesion G protein-coupled receptor L2
Names
CIRL-2
calcium-independent alpha-latrotoxin receptor 2
latrophilin-2
lectomedin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181013.1 → NP_851356.1  adhesion G protein-coupled receptor L2 precursor

    See identical proteins and their annotated locations for NP_851356.1

    Status: PROVISIONAL

    Source sequence(s)
    AF111084
    UniProtKB/Swiss-Prot
    O97805, O97807, O97809, O97810, O97811, O97812, O97813, O97814, O97815, O97816, O97817
    UniProtKB/TrEMBL
    A0A3Q1MQ77
    Related
    ENSBTAP00000073734.2, ENSBTAT00000067330.2
    Conserved Domains (7) summary
    smart00303
    Location:788 → 840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469 → 533
    HormR; Domain present in hormone receptors
    pfam00002
    Location:849 → 1099
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:49 → 129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1119 → 1478
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:543 → 762
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:142 → 398
    OLF; Olfactomedin-like domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    62437260..63147752 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O97817.1 GenPept UniProtKB/Swiss-Prot:O97817

Gene LinkOut

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