U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NEFL neurofilament light chain [ Bos taurus (domestic cattle) ]

Gene ID: 281348, updated on 27-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
NEFLprovided by VGNC
Official Full Name
neurofilament light chainprovided by VGNC
Primary source
VGNC:VGNC:31986
See related
BGD:BT25644; Ensembl:ENSBTAG00000021949
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See NEFL in Genome Data Viewer
Location:
chromosome: 8
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (72213269..72217537, complement)

Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 7 Neighboring gene neurofilament medium chain Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC100335268 Neighboring gene dedicator of cytokinesis 5

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Brain micro glutamic acid-rich protein is the C-terminal endpiece of the neurofilament 68-kDa protein as determined by the primary sequence. Isobe T, et al. FEBS Lett, 1985 Mar 25. PMID 3884373
  2. Identification of endogenous phosphorylation sites of bovine medium and low molecular weight neurofilament proteins by tandem mass spectrometry. Trimpin S, et al. Biochemistry, 2004 Feb 24. PMID 14967049
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC139791

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables structural constituent of postsynaptic intermediate filament cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in neurofilament bundle assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in postsynaptic intermediate filament cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
neurofilament light polypeptide
Names
68 kDa neurofilament protein
NF-L
micro glutamic acid-rich protein
neurofilament triplet L protein
neurofilament, light polypeptide 68kDa

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174121.1 → NP_776546.1  neurofilament light polypeptide

    See identical proteins and their annotated locations for NP_776546.1

    Status: PROVISIONAL

    Source sequence(s)
    U83919
    UniProtKB/Swiss-Prot
    P02548, P79127, Q17QQ0
    Related
    ENSBTAP00000029264.4, ENSBTAT00000029264.6
    Conserved Domains (4) summary
    pfam00038
    Location:89 → 400
    Filament; Intermediate filament protein
    pfam04732
    Location:9 → 88
    Filament_head; Intermediate filament head (DNA binding) region
    cd16269
    Location:212 → 222
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:140 → 239
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    72213269..72217537 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P02548.3 GenPept UniProtKB/Swiss-Prot:P02548

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.