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FURIN furin, paired basic amino acid cleaving enzyme [ Bos taurus (domestic cattle) ]

Gene ID: 281374, updated on 27-Dec-2024

Summary

Official Symbol
FURINprovided by VGNC
Official Full Name
furin, paired basic amino acid cleaving enzymeprovided by VGNC
Primary source
VGNC:VGNC:29146
See related
BGD:BT11212; Ensembl:ENSBTAG00000002939
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
PACE
Orthologs
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Genomic context

See FURIN in Genome Data Viewer
Location:
chromosome: 21
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 21 NC_037348.1 (21780691..21797132, complement)

Chromosome 21 - NC_037348.1Genomic Context describing neighboring genes Neighboring gene mannosidase alpha class 2A member 2 Neighboring gene FES proto-oncogene, tyrosine kinase Neighboring gene BLM RecQ like helicase Neighboring gene uncharacterized LOC107131599 Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene CREB regulated transcription coactivator 3

Genomic regions, transcripts, and products

Genomic Sequence:
NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

Expression

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

General gene information

Gene Ontology Provided by RefSeq

Component Evidence Code Pubs
located_in Golgi membrane PubMed 
located_in trans-Golgi network PubMed 

General protein information

Preferred Names
furin
Names
dibasic-processing enzyme
furin, membrane associated receptor protein
paired basic amino acid cleaving enzyme
paired basic amino acid residue-cleaving enzyme
trans Golgi network protease furin
NP_776561.1
XP_024837364.1
XP_024837365.1
XP_024837366.1
XP_059734924.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174136.2 → NP_776561.1  furin precursor

    Status: PROVISIONAL

    Source sequence(s)
    X75956
    UniProtKB/Swiss-Prot
    Q28193
    UniProtKB/TrEMBL
    A0A3Q1M727
    Related
    ENSBTAP00000065278.1, ENSBTAT00000072776.1
    Conserved Domains (5) summary
    cd04059
    Location:113 → 402
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:638 → 675
    FU; Furin-like repeats
    pfam00082
    Location:144 → 427
    Peptidase_S8; Subtilase family
    pfam01483
    Location:484 → 570
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33 → 107
    S8_pro-domain; Peptidase S8 pro-domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037348.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    21780691..21797132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059878941.1 → XP_059734924.1  furin isoform X1

    UniProtKB/TrEMBL
    A0A3Q1M727, B0JYR0
  2. XM_024981598.2 → XP_024837366.1  furin isoform X1

    UniProtKB/TrEMBL
    A0A3Q1M727, B0JYR0
    Conserved Domains (4) summary
    cd04059
    Location:113 → 402
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:638 → 675
    FU; Furin-like repeats
    pfam01483
    Location:484 → 570
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33 → 107
    S8_pro-domain; Peptidase S8 pro-domain
  3. XM_024981597.2 → XP_024837365.1  furin isoform X1

    UniProtKB/TrEMBL
    A0A3Q1M727, B0JYR0
    Conserved Domains (4) summary
    cd04059
    Location:113 → 402
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:638 → 675
    FU; Furin-like repeats
    pfam01483
    Location:484 → 570
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33 → 107
    S8_pro-domain; Peptidase S8 pro-domain
  4. XM_024981596.2 → XP_024837364.1  furin isoform X1

    UniProtKB/TrEMBL
    A0A3Q1M727, B0JYR0
    Conserved Domains (4) summary
    cd04059
    Location:113 → 402
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:638 → 675
    FU; Furin-like repeats
    pfam01483
    Location:484 → 570
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:33 → 107
    S8_pro-domain; Peptidase S8 pro-domain
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