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WASL WASP like actin nucleation promoting factor [ Bos taurus (domestic cattle) ]

Gene ID: 281577, updated on 27-Dec-2024

Summary

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Official Symbol
WASLprovided by VGNC
Official Full Name
WASP like actin nucleation promoting factorprovided by VGNC
Primary source
VGNC:VGNC:56336
See related
BGD:BT10329; Ensembl:ENSBTAG00000004643
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See WASL in Genome Data Viewer
Location:
chromosome: 4
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (87988369..88070047, complement)

Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box containing 15 Neighboring gene leiomodin 2 Neighboring gene small nucleolar RNA U3 Neighboring gene hyaluronidase 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Processive acceleration of actin barbed-end assembly by N-WASP. Khanduja N, et al. Mol Biol Cell, 2014 Jan. PMID 24227886, Free PMC Article
  2. N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases. Miki H, et al. EMBO J, 1996 Oct 1. PMID 8895577, Free PMC Article
  3. Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate. Rohatgi R, et al. J Cell Biol, 2000 Sep 18. PMID 10995436, Free PMC Article
  4. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Rohatgi R, et al. Cell, 1999 Apr 16. PMID 10219243
  5. Mechanism of filament nucleation and branch stability revealed by the structure of the Arp2/3 complex at actin branch junctions. Egile C, et al. PLoS Biol, 2005 Nov. PMID 16262445, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
actin nucleation-promoting factor WASL
Names
N-WASP
Wiskott-Aldrich syndrome like
neural Wiskott-Aldrich syndrome protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174219.2 → NP_776644.1  actin nucleation-promoting factor WASL

    See identical proteins and their annotated locations for NP_776644.1

    Status: PROVISIONAL

    Source sequence(s)
    D67066
    UniProtKB/Swiss-Prot
    Q95107
    UniProtKB/TrEMBL
    B0JYR3
    Related
    ENSBTAP00000006094.4, ENSBTAT00000006094.6
    Conserved Domains (4) summary
    smart00246
    Location:433 → 450
    WH2; Wiskott Aldrich syndrome homology region 2
    cd01205
    Location:40 → 138
    EVH1_WASP-like; WASP family proteins EVH1 domain
    pfam00786
    Location:202 → 258
    PBD; P21-Rho-binding domain
    pfam02205
    Location:402 → 425
    WH2; WH2 motif

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    87988369..88070047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010804401.3 → XP_010802703.1  actin nucleation-promoting factor WASL isoform X1

    UniProtKB/TrEMBL
    A0A3Q1M352, B0JYR3
    Related
    ENSBTAP00000062565.2, ENSBTAT00000075056.2
    Conserved Domains (4) summary
    smart00246
    Location:439 → 456
    WH2; Wiskott Aldrich syndrome homology region 2
    cd01205
    Location:40 → 138
    EVH1_WASP-like; WASP family proteins EVH1 domain
    pfam00786
    Location:202 → 259
    PBD; P21-Rho-binding domain
    pfam02205
    Location:408 → 431
    WH2; WH2 motif
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95107.1 GenPept UniProtKB/Swiss-Prot:Q95107

Gene LinkOut

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