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ABCA4 ATP binding cassette subfamily A member 4 [ Bos taurus (domestic cattle) ]

Gene ID: 281584, updated on 1-Jan-2025

Summary

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Official Symbol
ABCA4provided by VGNC
Official Full Name
ATP binding cassette subfamily A member 4provided by VGNC
Primary source
VGNC:VGNC:25458
See related
Ensembl:ENSBTAG00000018010
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
RmP
Orthologs
human mouse all
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Genomic context

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See ABCA4 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
50
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (49386861..49530772)

Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132344875 Neighboring gene uncharacterized LOC132344874 Neighboring gene Rho GTPase activating protein 29 Neighboring gene poly(rC)-binding protein 1-like Neighboring gene glutamate-cysteine ligase modifier subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Molecular organization and ATP-induced conformational changes of ABCA4, the photoreceptor-specific ABC transporter. Tsybovsky Y, et al. Structure, 2013 May 7. PMID 23562398, Free PMC Article
  2. N-retinylidene-phosphatidylethanolamine is the preferred retinoid substrate for the photoreceptor-specific ABC transporter ABCA4 (ABCR). Beharry S, et al. J Biol Chem, 2004 Dec 24. PMID 15471866
  3. Photoreceptor rim protein: partial sequences of cDNA show a high degree of similarity to ABC transporters. Thomson JL, et al. Curr Eye Res, 1997 Jul. PMID 9222095
  4. The 220-kDa rim protein of retinal rod outer segments is a member of the ABC transporter superfamily. Illing M, et al. J Biol Chem, 1997 Apr 11. PMID 9092582
  5. ATP-binding cassette transporter ABCA4 and chemical isomerization protect photoreceptor cells from the toxic accumulation of excess 11-cis-retinal. Quazi F, et al. Proc Natl Acad Sci U S A, 2014 Apr 1. PMID 24707049, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ABCA4 can transport N-11-cis-retinylidene-phosphatidylethanolamine (PE), the Schiff-base conjugate of 11-cis-retinal and PE, from the lumen to the cytoplasmic leaflet of disk membranes.
    Title: ATP-binding cassette transporter ABCA4 and chemical isomerization protect photoreceptor cells from the toxic accumulation of excess 11-cis-retinal.
  2. An 18 A-resolution structure of ABCA4 isolated from bovine rod outer segments was determined using electron microscopy and single-particle reconstruction
    Title: Molecular organization and ATP-induced conformational changes of ABCA4, the photoreceptor-specific ABC transporter.
  3. partial dephosphorylation of native bovine ABCA4 led to reduction of both basal and stimulated ATPase activity. Thus, we present the first evidence that phosphorylation of ABCA4 can regulate its function
    Title: Posttranslational modifications of the photoreceptor-specific ABC transporter ABCA4.
  4. results indicate that ATP binding cassette protein ABCA4 preferentially binds N-retinylidene-phosphatidylethanolamine with high affinity
    Title: N-retinylidene-phosphatidylethanolamine is the preferred retinoid substrate for the photoreceptor-specific ABC transporter ABCA4 (ABCR).
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATPase-coupled intramembrane lipid transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phospholipid transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
retinal-specific phospholipid-transporting ATPase ABCA4
Names
ATP-binding cassette sub-family A member 4
ATP-binding cassette, sub-family A (ABC1), member 4
RIM ABC transporter
RIM protein
retinal-specific ATP-binding cassette transporter
NP_776646.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174221.2 → NP_776646.1  retinal-specific phospholipid-transporting ATPase ABCA4

    See identical proteins and their annotated locations for NP_776646.1

    Status: PROVISIONAL

    Source sequence(s)
    U90126
    UniProtKB/Swiss-Prot
    F1MWM0, O02698
    Related
    ENSBTAP00000023982.5, ENSBTAT00000023982.6
    Conserved Domains (2) summary
    TIGR01257
    Location:1 → 2270
    rim_protein; retinal-specific rim ABC transporter
    cd03263
    Location:1936 → 2156
    ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    49386861..49530772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1MWM0.2 GenPept UniProtKB/Swiss-Prot:F1MWM0

Gene LinkOut

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