INSL3 insulin like 3 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: INSL3provided by VGNC
Official Full Name: insulin like 3provided by VGNC
Primary source: VGNC:VGNC:106785
See related: BGD:BT10450; Ensembl:ENSBTAG00000025775
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: RLF
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	7	NC_037334.1 (5325752..5327331)

Chromosome 7 - NC_037334.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

plasma insulin-like peptide 3, testosterone, inhibin, and insulin-like growth factor-I have a relationship with scrotal circumference and testicular weight in Japanese Black beef bull calves
Title: Relationships of plasma insulin-like peptide 3, testosterone, inhibin, and insulin-like growth factor-I concentrations with scrotal circumference and testicular weight in Japanese Black beef bull calves.
These results suggest that reduced secretions of IGF-I, INSL3, and inhibin surrounding puberty may be associated with semen aberration in beef bulls.
Title: Plasma IGF-I, INSL3, testosterone, inhibin concentrations and scrotal circumferences surrounding puberty in Japanese Black beef bulls with normal and abnormal semen.
These results suggested an acute regulation of INSL3 by luteinizing hormone (LH) because INSL3 concentrations increased immediately after endogenous and exogenous LH stimulation.
Title: Plasma insulin-like peptide 3 concentrations are acutely regulated by luteinizing hormone in pubertal Japanese Black beef bulls.
INSL3 plays a luteotropic role as a local regulator in the bovine corpus luteum.
Title: Possible role of insulin-like factor 3 in the bovine corpus luteum.
BMP6 has a role in downregulating INSL3 and CYP17A1 and other proteins that modulate ovarian androgen production
Title: Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production.
The likely role of INSL3 as an important intrafollicular modulator of thecal interna cell function/steroidogenesis.
Title: Ovarian expression of insulin-like peptide 3 (INSL3) and its receptor (RXFP2) during development of bovine antral follicles and corpora lutea and measurement of circulating INSL3 levels during synchronized estrous cycles.
INSL3 provides the first example of a gender-specific fetal hormone with the potential to influence both placental and maternal physiology
Title: INSL3 in the ruminant: a powerful indicator of gender- and genetic-specific feto-maternal dialogue.
relaxin-like factor mRNA was highly expressed in the corpus luteum on days 7 and 14 of pregnancy
Title: Immunohistochemical localization of relaxin-like factor/insulin-like peptide-3 in the bovine corpus luteum.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables hormone activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: insulin-like 3

Names: insulin-like 3 (Leydig cell); insulin-like peptide-3; ley-I-L; leydig insulin-like peptide; relaxin-like factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174365.2 → NP_776790.1 insulin-like 3 precursor

See identical proteins and their annotated locations for NP_776790.1

Status: PROVISIONAL

Source sequence(s)

AF094580

UniProtKB/Swiss-Prot

O77801, Q3T065

Related

ENSBTAP00000027848.4, ENSBTAT00000027848.5

Conserved Domains (1) summary

cd04365
Location:32 → 130

IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...