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PDE6B phosphodiesterase 6B [ Bos taurus (domestic cattle) ]

Gene ID: 281974, updated on 30-Jan-2025

Summary

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Official Symbol
PDE6Bprovided by VGNC
Official Full Name
phosphodiesterase 6Bprovided by VGNC
Primary source
VGNC:VGNC:32680
See related
EnsemblRapid:ENSBTAG00070000103
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See PDE6B in Genome Data Viewer
Location:
chromosome: 6
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 6 NC_037333.1 (117653872..117685792, complement)

Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 49 member 3 Neighboring gene microRNA mir-11993 Neighboring gene myosin light chain 5 Neighboring gene ATP synthase membrane subunit e Neighboring gene beclin-1-like Neighboring gene transmembrane protein 271

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. [Cyclic GMP phosphodiesterase from bovine retina. Amino acid sequence of beta-subunit and nucleotide sequence of corresponding cDNA]. Lipkin VM, et al. Bioorg Khim, 1990 Jan. PMID 2161230
  2. Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6. Gao Y, et al. Mol Cell, 2020 Oct 15. PMID 33007200, Free PMC Article
  3. The molecular architecture of photoreceptor phosphodiesterase 6 (PDE6) with activated G protein elucidates the mechanism of visual excitation. Irwin MJ, et al. J Biol Chem, 2019 Dec 20. PMID 31690623, Free PMC Article
  4. Allosteric Regulation of Rod Photoreceptor Phosphodiesterase 6 (PDE6) Elucidated by Chemical Cross-Linking and Quantitative Mass Spectrometry. Chu F, et al. J Mol Biol, 2019 Sep 6. PMID 31394113, Free PMC Article
  5. Domain organization and conformational plasticity of the G protein effector, PDE6. Zhang Z, et al. J Biol Chem, 2015 May 15. PMID 25809480, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6.
    Title: Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6.
  2. Analysis of the Rod PDE6 holoenzyme (subunit composition, alphabetagammagamma) reveals the mechanism of visual excitation
    Title: The molecular architecture of photoreceptor phosphodiesterase 6 (PDE6) with activated G protein elucidates the mechanism of visual excitation.
  3. a structural basis for interpreting how mutations in rod PDE6 subunits can lead to retinal diseases, is discussed.
    Title: Allosteric Regulation of Rod Photoreceptor Phosphodiesterase 6 (PDE6) Elucidated by Chemical Cross-Linking and Quantitative Mass Spectrometry.
  4. The approximately 11 A map revealed previously unseen features of PDE6, and each domain was readily fit with high resolution structures.
    Title: Domain organization and conformational plasticity of the G protein effector, PDE6.
  5. although Pgamma-mediated regulation plays the dominant role in visual excitation, the direct, inter-domain allosteric regulation may play a feedback role in light adaptational processes during phototransduction
    Title: Direct allosteric regulation between the GAF domain and catalytic domain of photoreceptor phosphodiesterase PDE6.
  6. Structural analysis of cGMP phosphodiesterase 6 alpha, beta and gamma interactions
    Title: Three-dimensional structure of non-activated cGMP phosphodiesterase 6 and comparison of its image with those of activated forms.
  7. the unique Palphabeta heterodimer contributes to the sophisticated regulation in visual transduction through interaction with Pgamma
    Title: Asymmetric interaction between rod cyclic GMP phosphodiesterase gamma subunits and alphabeta subunits.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in retina development in camera-type eye IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in photoreceptor outer segment membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
Names
GMP-PDE beta
phosphodiesterase 6B, cGMP-specific, rod, beta (congenital stationary night blindness 3, autosomal dominant)
phosphodiesterase, cyclic GMP ( rod receptor), beta polypeptide
NP_776843.1
XP_059743302.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174418.1 → NP_776843.1  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

    See identical proteins and their annotated locations for NP_776843.1

    Status: PROVISIONAL

    Source sequence(s)
    J05553
    UniProtKB/Swiss-Prot
    P23439
    UniProtKB/TrEMBL
    F1N0U0
    Related
    ENSBTAP00070000129.1, ENSBTAT00070000184.1
    Conserved Domains (2) summary
    smart00065
    Location:71 → 230
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:556 → 801
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    117653872..117685792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059887319.1 → XP_059743302.1  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23439.1 GenPept UniProtKB/Swiss-Prot:P23439

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials