PRDX4 peroxiredoxin 4 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: PRDX4provided by VGNC
Official Full Name: peroxiredoxin 4provided by VGNC
Primary source: VGNC:VGNC:33302
See related: BGD:BT19017; Ensembl:ENSBTAG00000006165
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: X

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	X	NC_037357.1 (119515820..119531948, complement)

Chromosome X - NC_037357.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

CC485137 (e-PCR)
- UniSTS:477274

D1S2039E (e-PCR)
- UniSTS:151466

PRDX4 (e-PCR)
- UniSTS:506545

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables thioredoxin peroxidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to stress	IEA Inferred from Electronic Annotation more info	PubMed
involved_in hydrogen peroxide catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: peroxiredoxin-4

Names: peroxiredoxin IV; prx-IV; thioredoxin-dependent peroxiredoxin 4

NP_776858.1

EC 1.11.1.24

XP_059739265.1

EC 1.11.1.24

XP_059739267.1

EC 1.11.1.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174433.2 → NP_776858.1 peroxiredoxin-4 precursor

See identical proteins and their annotated locations for NP_776858.1

Status: PROVISIONAL

Source sequence(s)

AF305563

UniProtKB/Swiss-Prot

Q32L06, Q9BGI2

UniProtKB/TrEMBL

A0A3Q1LW10

Related

ENSBTAP00000008107.4, ENSBTAT00000008107.4

Conserved Domains (1) summary

cd03015
Location:84 → 255

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...