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PRKCA protein kinase C alpha [ Bos taurus (domestic cattle) ]

Gene ID: 282001, updated on 29-Jan-2025

Summary

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Official Symbol
PRKCAprovided by VGNC
Official Full Name
protein kinase C alphaprovided by VGNC
Primary source
VGNC:VGNC:33327
See related
BGD:BT10523
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
PKRCA
Orthologs
human mouse all
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Genomic context

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See PRKCA in Genome Data Viewer
Location:
chromosome: 19
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (62664528..62975086)

Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene apolipoprotein H Neighboring gene uncharacterized LOC107131551 Neighboring gene microRNA mir-2284p Neighboring gene uncharacterized LOC132343139 Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 5 Neighboring gene uncharacterized LOC132343138

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Unloading of intercellular tension induces the directional translocation of PKCα. Sera T, et al. J Cell Physiol, 2019 Jun. PMID 30387146
  2. Phosphorylation of protein kinase C-alpha on serine 657 controls the accumulation of active enzyme and contributes to its phosphatase-resistant state. Bornancin F, et al. J Biol Chem, 1997 Feb 7. PMID 9013603
  3. Ceramide induces translocation of protein kinase C-alpha to the Golgi compartment of human embryonic kidney cells by interacting with the C2 domain. Aschrafi A, et al. Biochim Biophys Acta, 2003 Oct 20. PMID 14563411
  4. The last 10 amino acid residues beyond the hydrophobic motif are critical for the catalytic competence and function of protein kinase Calpha. Yeong SS, et al. J Biol Chem, 2006 Oct 13. PMID 16895917
  5. Endoplasmic reticulum distribution during bovine oocyte activation is regulated by protein kinase C via actin filaments. Feitosa WB, et al. J Cell Physiol, 2020 Jul. PMID 31960444

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Endoplasmic reticulum distribution during bovine oocyte activation is regulated by protein kinase C via actin filaments.
    Title: Endoplasmic reticulum distribution during bovine oocyte activation is regulated by protein kinase C via actin filaments.
  2. The results of this study indicate the involvement of PKCalpha in the Ca (2+) signaling pathway in response to mechanical stress in endothelial cells.
    Title: Unloading of intercellular tension induces the directional translocation of PKCα.
  3. Mechanical stress induced biphasic and directional PKCalpha translocation
    Title: Spatial and temporal translocation of PKCα in single endothelial cell in response to mechanical stimulus.
  4. AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
    Title: Protein kinase C and Src family kinases mediate angiotensin II-induced protein kinase D activation and acute aldosterone production.
  5. Significant changes in thin filament Ca2+-sensitivity, structure and kinetics are brought about through PKC phosphorylation of cardiac troponin T.
    Title: FRET study of the structural and kinetic effects of PKC phosphomimetic cardiac troponin T mutants on thin filament regulation.
  6. Data indicate the involvement of PKC-alpha in proMMP-2 activation and inhibition of TIMP-2 expression by NF-kappaB-MT1-MMP-dependent and -independent pathway.
    Title: Role of PKC-α in NF-κB-MT1-MMP-mediated activation of proMMP-2 by TNF-α in pulmonary artery smooth muscle cells.
  7. calcium-dependent phosphorylation of argininosuccinate synthase Ser-328 is mediated by PKCalpha
    Title: Protein kinase Cα phosphorylates a novel argininosuccinate synthase site at serine 328 during calcium-dependent stimulation of endothelial nitric-oxide synthase in vascular endothelial cells.
  8. VDAC phosphorylation is an important determinant of its interaction with dimeric tubulin.
    Title: Phosphorylation of voltage-dependent anion channel by serine/threonine kinases governs its interaction with tubulin.
  9. Using yeast cells co-expressing the human wild-type p53 and a single mammalian PKCalpha, delta, epsilon or zeta, results showed a differential regulation of p53-mediated apoptosis by these PKC isoforms.
    Title: Distinct regulation of p53-mediated apoptosis by protein kinase Cα, δ, ε and ζ: Evidence in yeast for transcription-dependent and -independent p53 apoptotic mechanisms.
  10. degradation of protein kinase C(alpha)in sperm capacitation is mediated by PRKA
    Title: Protein kinase A and protein kinase C(alpha)/PPP1CC2 play opposing roles in the regulation of phosphatidylinositol 3-kinase activation in bovine sperm.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein kinase C alpha type
Names
PKC-A
PKC-alpha
NP_776860.1
XP_024835381.1
XP_024835382.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174435.1 → NP_776860.1  protein kinase C alpha type

    See identical proteins and their annotated locations for NP_776860.1

    Status: PROVISIONAL

    Source sequence(s)
    M13973
    UniProtKB/Swiss-Prot
    P04409
    UniProtKB/TrEMBL
    B0JYP1
    Related
    ENSBTAP00070010143.1, ENSBTAT00070017450.1
    Conserved Domains (4) summary
    cd04026
    Location:159 → 289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    smart00220
    Location:339 → 597
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05615
    Location:328 → 668
    STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
    pfam00130
    Location:37 → 89
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    62664528..62975086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024979613.2 → XP_024835381.1  protein kinase C alpha type isoform X1

    UniProtKB/TrEMBL
    B0JYP1
    Conserved Domains (3) summary
    cd04026
    Location:159 → 289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05615
    Location:328 → 684
    STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
    pfam00130
    Location:37 → 89
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  2. XM_024979614.2 → XP_024835382.1  protein kinase C alpha type isoform X2

    UniProtKB/TrEMBL
    B0JYP1
    Related
    ENSBTAP00070010140.1, ENSBTAT00070017447.1
    Conserved Domains (3) summary
    cd04026
    Location:159 → 289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05587
    Location:342 → 620
    STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
    pfam00130
    Location:37 → 89
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04409.3 GenPept UniProtKB/Swiss-Prot:P04409

Gene LinkOut

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