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PRKG1 protein kinase cGMP-dependent 1 [ Bos taurus (domestic cattle) ]

Gene ID: 282004, updated on 27-Dec-2024

Summary

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Official Symbol
PRKG1provided by VGNC
Official Full Name
protein kinase cGMP-dependent 1provided by VGNC
Primary source
VGNC:VGNC:33340
See related
BGD:BT19454; Ensembl:ENSBTAG00000018404
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
CGKI; cGK 1; cGKI-beta
Orthologs
human mouse all
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Genomic context

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See PRKG1 in Genome Data Viewer
Location:
chromosome: 26
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 26 NC_037353.1 (6895298..8313728, complement)

Chromosome 26 - NC_037353.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132343933 Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene dickkopf WNT signaling pathway inhibitor 1 Neighboring gene uncharacterized LOC132343934 Neighboring gene cleavage stimulation factor subunit 2 tau variant Neighboring gene uncharacterized LOC112444473 Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene APOBEC1 complementation factor Neighboring gene N-acylsphingosine amidohydrolase 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037353.1 Chromosome 26 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Downregulation of cGMP-dependent protein kinase expression by inflammatory cytokines in vascular smooth muscle cells. Browner NC, et al. Am J Physiol Cell Physiol, 2004 Jul. PMID 14985234
  2. Properties of a cGMP-dependent monomeric protein kinase from bovine aorta. Wolfe L, et al. J Biol Chem, 1989 Mar 5. PMID 2537306
  3. The cDNA of the two isoforms of bovine cGMP-dependent protein kinase. Wernet W, et al. FEBS Lett, 1989 Jul 17. PMID 2546820
  4. A catalytically active fragment of cGMP-dependent protein kinase. Occupation of its cGMP-binding sites does not affect its phosphotransferase activity. Heil WG, et al. Eur J Biochem, 1987 Oct 1. PMID 2822399
  5. Guanosine cyclic 3',5'-phosphate dependent protein kinase, a chimeric protein homologous with two separate protein families. Takio K, et al. Biochemistry, 1984 Aug 28. PMID 6091741

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NADPH regulation of PKG1-alpha dimerization may contribute to vascular responses to hypoxia that are associated with changes in NADPH redox.
    Title: Roles for cytosolic NADPH redox in regulating pulmonary artery relaxation by thiol oxidation-elicited subunit dimerization of protein kinase G1α.
  2. The data suggest that PKG-I expression is subjected to post-transcriptional regulation in VSMC through the 3'UTR of its mRNA.
    Title: Stabilization of cGMP-dependent protein kinase G (PKG) expression in vascular smooth muscle cells: contribution of 3'UTR of its mRNA.
  3. Report roles for redox mechanisms controlling protein kinase G in pulmonary and coronary artery responses to hypoxia.
    Title: Roles for redox mechanisms controlling protein kinase G in pulmonary and coronary artery responses to hypoxia.
  4. Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication
    Title: Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication.
  5. cGMP-dependent protein kinase expression is regulated by soluble guanylyl cyclase in vascular smooth muscle cells
    Title: Regulation of cGMP-dependent protein kinase expression by soluble guanylyl cyclase in vascular smooth muscle cells.
  6. studies suggest that cross-activation of PKA in response to iNOS expression by inflammatory mediators downregulates cGMP-dependent protein kinase expression in bovine aortic vascular smooth muscle cells
    Title: Downregulation of cGMP-dependent protein kinase expression by inflammatory cytokines in vascular smooth muscle cells.
  7. cGMP-dependent protein kinase Ibeta binds to TFII-I and IRAG through a common interaction motif
    Title: Identification of the interface between cGMP-dependent protein kinase Ibeta and its interaction partners TFII-I and IRAG reveals a common interaction motif.
  8. purified cGMP kinase signaling complex contained alpha-actin, calponin H1, and phospholamban
    Title: Association of phospholamban with a cGMP kinase signaling complex.
  9. Demonstrate a novel PKG-dependent pathway by which the Rac1/Pak1 pathway is activated.
    Title: Activation of the small GTPase Rac1 by cGMP-dependent protein kinase.
  10. cGMP binding destabilizes the N-terminus of cGMP-dependent protein kinase I alpha isozyme at the hinge region, centered around residue 77, while the C-terminus is protected from degradation.
    Title: The hinge region operates as a stability switch in cGMP-dependent protein kinase I alpha.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cGMP-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cGMP-dependent protein kinase 1
Names
CGK 1 alpha
cGK 1 beta
cGK1
cGKI-alpha
cGMP-dependent protein kinase 1, alpha isozyme
cGMP-dependent protein kinase 1, beta isozyme
cGMP-dependent protein kinase I
protein kinase, cGMP-dependent, type I
NP_776861.1
XP_005225410.2
XP_059737716.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174436.2 → NP_776861.1  cGMP-dependent protein kinase 1

    See identical proteins and their annotated locations for NP_776861.1

    Status: PROVISIONAL

    Source sequence(s)
    X16086
    UniProtKB/Swiss-Prot
    P00516, P21136
    Conserved Domains (4) summary
    cd12085
    Location:2 → 49
    DD_cGKI-alpha; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I alpha
    smart00133
    Location:621 → 664
    S_TK_X; Extension to Ser/Thr-type protein kinases
    cd00038
    Location:222 → 326
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd05572
    Location:366 → 626
    STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037353.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    6895298..8313728 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005225353.4 → XP_005225410.2  cGMP-dependent protein kinase 1 isoform X1

    Conserved Domains (4) summary
    cd12086
    Location:4 → 55
    DD_cGKI-beta; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I beta
    smart00133
    Location:636 → 679
    S_TK_X; Extension to Ser/Thr-type protein kinases
    cd00038
    Location:237 → 341
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd05572
    Location:381 → 641
    STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)

  2. XM_059881733.1 → XP_059737716.1  cGMP-dependent protein kinase 1 isoform X2

    Related
    ENSBTAP00000024490.6, ENSBTAT00000024490.7
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00516.2 GenPept UniProtKB/Swiss-Prot:P00516

Gene LinkOut

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