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RPH3A rabphilin 3A [ Bos taurus (domestic cattle) ]

Gene ID: 282044, updated on 29-Jan-2025

Summary

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Official Symbol
RPH3Aprovided by VGNC
Official Full Name
rabphilin 3Aprovided by VGNC
Primary source
VGNC:VGNC:34106
See related
BGD:BT23029; Ensembl:ENSBTAG00000004247
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See RPH3A in Genome Data Viewer
Location:
chromosome: 17
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 17 NC_037344.1 (61407229..61700264, complement)

Chromosome 17 - NC_037344.1Genomic Context describing neighboring genes Neighboring gene 2',5'-oligoadenylate synthetase 1, 40/46kDa Neighboring gene 2',5'-oligoadenylate synthetase 1, 40/46kDa Neighboring gene protein tyrosine phosphatase non-receptor type 11 Neighboring gene U6 spliceosomal RNA Neighboring gene ribosomal protein L6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037344.1 Chromosome 17 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Rabphilin-3A, a putative target protein for smg p25A/rab3A p25 small GTP-binding protein related to synaptotagmin. Shirataki H, et al. Mol Cell Biol, 1993 Apr. PMID 8384302, Free PMC Article
  2. Two functionally different domains of rabphilin-3A, Rab3A p25/smg p25A-binding and phospholipid- and Ca(2+)-binding domains. Yamaguchi T, et al. J Biol Chem, 1993 Dec 25. PMID 8262955
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of calcium ion-dependent exocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in spontaneous neurotransmitter secretion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extrinsic component of synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rabphilin-3A
Names
exophilin-1
rabphilin 3A homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174454.3 → NP_776879.1  rabphilin-3A

    See identical proteins and their annotated locations for NP_776879.1

    Status: PROVISIONAL

    Source sequence(s)
    D13613
    UniProtKB/Swiss-Prot
    Q06846
    UniProtKB/TrEMBL
    A6QR65
    Related
    ENSBTAP00070034861.1, ENSBTAT00070058659.1
    Conserved Domains (3) summary
    cd04035
    Location:403 → 526
    C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
    cd08384
    Location:563 → 695
    C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain
    cd15762
    Location:92 → 172
    FYVE_RP3A; FYVE-related domain found in rabphilin-3A and similar proteins

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037344.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    61407229..61700264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059875879.1 → XP_059731862.1  rabphilin-3A isoform X1

    UniProtKB/TrEMBL
    A0AAA9SZ60, A6QR65

  2. XM_059875878.1 → XP_059731861.1  rabphilin-3A isoform X1

    UniProtKB/TrEMBL
    A0AAA9SZ60, A6QR65

  3. XM_059875880.1 → XP_059731863.1  rabphilin-3A isoform X1

    UniProtKB/TrEMBL
    A0AAA9SZ60, A6QR65
    Related
    ENSBTAP00070034878.1, ENSBTAT00070058699.1

  4. XM_059875881.1 → XP_059731864.1  rabphilin-3A isoform X1

    UniProtKB/TrEMBL
    A0AAA9SZ60, A6QR65
    Related
    ENSBTAP00070034886.1, ENSBTAT00070058715.1

  5. XM_059875877.1 → XP_059731860.1  rabphilin-3A isoform X1

    UniProtKB/TrEMBL
    A0AAA9SZ60, A6QR65

  6. XM_024977012.2 → XP_024832780.1  rabphilin-3A isoform X1

    UniProtKB/TrEMBL
    A0AAA9SZ60, A6QR65
    Conserved Domains (4) summary
    cd04035
    Location:399 → 522
    C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
    cd08384
    Location:559 → 691
    C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain
    cd15762
    Location:88 → 168
    FYVE_RP3A; FYVE-related domain found in rabphilin-3A and similar proteins
    cl26386
    Location:177 → 376
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

  7. XM_059875882.1 → XP_059731865.1  rabphilin-3A isoform X1

    UniProtKB/TrEMBL
    A0AAA9SZ60, A6QR65

  8. XM_059875876.1 → XP_059731859.1  rabphilin-3A isoform X1

    UniProtKB/TrEMBL
    A0AAA9SZ60, A6QR65
    Related
    ENSBTAP00070034869.1, ENSBTAT00070058678.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06846.1 GenPept UniProtKB/Swiss-Prot:Q06846

Gene LinkOut

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Molecular Biology Databases
Research Materials