SFRP5 secreted frizzled related protein 5 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: SFRP5provided by VGNC
Official Full Name: secreted frizzled related protein 5provided by VGNC
Primary source: VGNC:VGNC:34523
See related: BGD:BT16197; Ensembl:ENSBTAG00000018566
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 26

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	26	NC_037353.1 (18914372..18919213, complement)

Chromosome 26 - NC_037353.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037353.1 Chromosome 26 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

Sfrp5 (e-PCR), detects polymorphism
- UniSTS:525512

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables Wnt-protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in non-canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: secreted frizzled-related protein 5

Names: sFRP-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174461.3 → NP_776886.1 secreted frizzled-related protein 5 precursor

See identical proteins and their annotated locations for NP_776886.1

Status: VALIDATED

Source sequence(s)

DAAA02058918

UniProtKB/Swiss-Prot

A6QP61, Q9XSC1

Related

ENSBTAP00070039445.1, ENSBTAT00070065349.1

Conserved Domains (2) summary

cd07444
Location:45 → 171

CRD_SFRP5; Cysteine-rich domain of the secreted frizzled-related protein 5 (SFRP5), a regulator of Wnt activity

cd03580
Location:176 → 301

NTR_Sfrp1_like; NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse ...