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TGFB1 transforming growth factor beta 1 [ Bos taurus (domestic cattle) ]

Gene ID: 282089, updated on 30-Jan-2025

Summary

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Official Symbol
TGFB1provided by VGNC
Official Full Name
transforming growth factor beta 1provided by VGNC
Primary source
VGNC:VGNC:35800
See related
EnsemblRapid:ENSBTAG00070016868
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See TGFB1 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (50473691..50508349, complement)

Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 2 subfamily S member 1 Neighboring gene AXL receptor tyrosine kinase Neighboring gene uncharacterized LOC132342854 Neighboring gene heterogeneous nuclear ribonucleoprotein U like 1 Neighboring gene coiled-coil domain containing 97 Neighboring gene B9 domain containing 2 Neighboring gene transmembrane protein 91

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Delayed parturition in cloned calves associated with persistently elevated placentomal TGF-beta1 expression. Hwang S, et al. Anim Reprod Sci, 2009 Oct. PMID 19167845
  2. Transforming growth factor-beta isoform expression during bovine ovarian antral follicle development. Nilsson EE, et al. Mol Reprod Dev, 2003 Nov. PMID 14502602
  3. Apoptosis and autophagy in involuting bovine mammary gland is accompanied by up-regulation of TGF-beta1 and suppression of somatotropic pathway. Zarzyńska J, et al. Pol J Vet Sci, 2007. PMID 17388018
  4. TGF-beta1 increases proliferation of airway smooth muscle cells by phosphorylation of map kinases. Chen G, et al. Respir Res, 2006 Jan 3. PMID 16390551, Free PMC Article
  5. Effects of transforming growth factor-β on mammary remodeling during the dry period of dairy cows. Vries LD, et al. J Dairy Sci, 2011 Dec. PMID 22118091

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Modulatory effects of TGF-beta1 and BMP6 on thecal angiogenesis and steroidogenesis in the bovine ovary.
    Title: Modulatory effects of TGF-β1 and BMP6 on thecal angiogenesis and steroidogenesis in the bovine ovary.
  2. These data support the contention that FGF2 and TGFB1 modulate THBS1 via miR-221.
    Title: Fibroblast growth factor-2 and transforming growth factor-beta1 oppositely regulate miR-221 that targets thrombospondin-1 in bovine luteal endothelial cells.
  3. TGF-beta1 stimulated lubricin secretion by superficial zone chondrocytes at all densities with twice-a-week TGF-beta treatment. It is noteworthy that the daily treatment of TGF-beta1 increased lubricin much higher compared with twice-a-week treatment.
    Title: Optimization of Methods for Articular Cartilage Surface Tissue Engineering: Cell Density and Transforming Growth Factor Beta Are Critical for Self-Assembly and Lubricin Secretion.
  4. hypoxia increased the expression of platelet-derived growth factor (PDGF) and transforming growth factor-beta1 (TGF-beta1) and decreased the expression of neprilysin (NEP), which contributed to the hypoxia-induced Endothelial-to-mesenchymal transition of pulmonary artery endothelial cells.
    Title: The role of PDGF-B/TGF-β1/neprilysin network in regulating endothelial-to-mesenchymal transition in pulmonary artery remodeling.
  5. TGF-beta1 modulates the expression of syndecan-4 in cultured vascular endothelial cells in a biphasic manner.
    Title: Transforming Growth Factor-β(1) Modulates the Expression of Syndecan-4 in Cultured Vascular Endothelial Cells in a Biphasic Manner.
  6. Taken together, Staphylococcus aureus induces TGF-beta1 and bFGF expression through the activation of AP-1 and NF-kappaB in bovine mammary gland fibroblasts.
    Title: Staphylococcus aureus induces TGF-β1 and bFGF expression through the activation of AP-1 and NF-κB transcription factors in bovine mammary gland fibroblasts.
  7. localized to maternal septum in the interdigitation area of cotyledonary villi and caruncle
    Title: Localization of TGF-β and TGF-β receptor in bovine term placentome and expression differences between spontaneous and induced parturition.
  8. The results identify TGFB1 and ESRRA as likely transcriptional regulators of rumen epithelial development and energy metabolism, respectively, and provide targets for modulation of rumen development and function in the growing calf.
    Title: Transcriptional regulators transforming growth factor-β1 and estrogen-related receptor-α identified as putative mediators of calf rumen epithelial tissue development and function during weaning.
  9. the combined treatment with TGF-beta1 and BMP-7 or treatment first with TGF-beta1 followed by BMP-7 was more effective than other treatment groups in both chondrogenic differentiation and SZP secretion.
    Title: Induction of chondrogenesis and expression of superficial zone protein in synovial explants with TGF-β1 and BMP-7.
  10. Tenascin-X promotes activation of latent TGF-beta1 and subsequent epithelial to mesenchymal transition in mammary epithelial cells.
    Title: Tenascin-X promotes epithelial-to-mesenchymal transition by activating latent TGF-β.
Submit: New GeneRIF Correction See all GeneRIFs (32)

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transforming growth factor beta receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
transforming growth factor beta-1 proprotein
Names
TGF-beta-1
transforming growth factor, beta 1 (Camurati-Engelmann disease)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166068.1 → NP_001159540.1  transforming growth factor beta-1 proprotein precursor

    Status: VALIDATED

    Source sequence(s)
    DY089185, M36271
    UniProtKB/Swiss-Prot
    A5A3B8, P18341
    Conserved Domains (2) summary
    smart00204
    Location:293 → 390
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:29 → 261
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    50473691..50508349 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024977950.2 → XP_024833718.1  transforming growth factor beta-1 proprotein isoform X2

    UniProtKB/TrEMBL
    A0A3Q1N449, A0A3Q1NIZ0
    Related
    ENSBTAP00070022255.1, ENSBTAT00070037856.1
    Conserved Domains (2) summary
    pfam00688
    Location:29 → 261
    TGFb_propeptide; TGF-beta propeptide
    cl02510
    Location:293 → 333
    TGF_beta; Transforming growth factor beta like domain

  2. XM_059876513.1 → XP_059732496.1  transforming growth factor beta-1 proprotein isoform X3

    UniProtKB/TrEMBL
    A0A3Q1NIZ0
    Related
    ENSBTAP00070022256.1, ENSBTAT00070037858.1

  3. XM_024977949.2 → XP_024833717.1  transforming growth factor beta-1 proprotein isoform X1

    UniProtKB/TrEMBL
    A0A3Q1NIZ0
    Conserved Domains (2) summary
    pfam00688
    Location:29 → 262
    TGFb_propeptide; TGF-beta propeptide
    cl02510
    Location:294 → 334
    TGF_beta; Transforming growth factor beta like domain

  4. XM_024977951.2 → XP_024833719.1  transforming growth factor beta-1 proprotein isoform X4

    UniProtKB/TrEMBL
    E1BNK3
    Related
    ENSBTAP00070022247.1, ENSBTAT00070037843.1
    Conserved Domains (2) summary
    smart00204
    Location:294 → 391
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:29 → 262
    TGFb_propeptide; TGF-beta propeptide
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18341.2 GenPept UniProtKB/Swiss-Prot:P18341

Gene LinkOut

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Molecular Biology Databases
Research Materials