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TRPC1 transient receptor potential cation channel subfamily C member 1 [ Bos taurus (domestic cattle) ]

Gene ID: 282100, updated on 29-Jan-2025

Summary

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Official Symbol
TRPC1provided by VGNC
Official Full Name
transient receptor potential cation channel subfamily C member 1provided by VGNC
Primary source
VGNC:VGNC:36381
See related
Ensembl:ENSBTAG00000002232
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
TRP-1
Orthologs
human mouse all
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Genomic context

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See TRPC1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (126257858..126320448, complement)

Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene progestin and adipoQ receptor family member 9 Neighboring gene ferritin light chain Neighboring gene procollagen C-endopeptidase enhancer 2 Neighboring gene plastin 1 Neighboring gene uncharacterized LOC100847999 Neighboring gene transfer RNA glycine (anticodon UCC)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Glucose enhances expression of TRPC1 and calcium entry in endothelial cells. Bishara NB, et al. Am J Physiol Heart Circ Physiol, 2010 Jan. PMID 19855058
  2. Concomitant and hormonally regulated expression of trp genes in bovine aortic endothelial cells. Chang AS, et al. FEBS Lett, 1997 Oct 6. PMID 9357995
  3. Interaction between TRPC channel subunits in endothelial cells. Antoniotti S, et al. J Recept Signal Transduct Res, 2006. PMID 16818374
  4. Two types of non-selective cation channel opened by muscarinic stimulation with carbachol in bovine ciliary muscle cells. Takai Y, et al. J Physiol, 2004 Sep 15. PMID 15272043, Free PMC Article
  5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the link between HG-induced changes in TRPC1 expression, enhanced Ca(2+) entry, and endothelial dysfunction require further study
    Title: Glucose enhances expression of TRPC1 and calcium entry in endothelial cells.
  2. TRPC channel subunits 1 and 4 interact in bovine endothelial cells
    Title: Interaction between TRPC channel subunits in endothelial cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables inositol 1,4,5 trisphosphate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables store-operated calcium channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of cation channel complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
short transient receptor potential channel 1
Names
transient receptor potential channel 1
transient receptor protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174476.3 → NP_776901.2  short transient receptor potential channel 1

    Status: VALIDATED

    Source sequence(s)
    NKLS02000001
    Related
    ENSBTAP00070003846.1, ENSBTAT00070006671.1

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    126257858..126320448 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005201850.5 → XP_005201907.1  short transient receptor potential channel 1 isoform X6

    UniProtKB/TrEMBL
    A7VJS3
    Conserved Domains (2) summary
    pfam00520
    Location:291 → 537
    Ion_trans; Ion transport protein
    pfam08344
    Location:61 → 119
    TRP_2; Transient receptor ion channel II

  2. XM_005201849.5 → XP_005201906.1  short transient receptor potential channel 1 isoform X5

    UniProtKB/TrEMBL
    A7VJS3
    Conserved Domains (2) summary
    pfam00520
    Location:325 → 571
    Ion_trans; Ion transport protein
    pfam08344
    Location:95 → 153
    TRP_2; Transient receptor ion channel II

  3. XM_005201848.5 → XP_005201905.1  short transient receptor potential channel 1 isoform X4

    UniProtKB/TrEMBL
    A7VJS3, F1MG34
    Related
    ENSBTAP00070003827.1, ENSBTAT00070006622.1
    Conserved Domains (4) summary
    cd00204
    Location:52 → 147
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:49 → 741
    trp; transient-receptor-potential calcium channel protein
    pfam08344
    Location:160 → 218
    TRP_2; Transient receptor ion channel II
    sd00045
    Location:84 → 118
    ANK; ANK repeat [structural motif]

  4. XM_005201847.5 → XP_005201904.1  short transient receptor potential channel 1 isoform X3

    UniProtKB/TrEMBL
    A7VJS3
    Conserved Domains (4) summary
    cd00204
    Location:52 → 147
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:49 → 753
    trp; transient-receptor-potential calcium channel protein
    pfam08344
    Location:160 → 218
    TRP_2; Transient receptor ion channel II
    sd00045
    Location:84 → 118
    ANK; ANK repeat [structural motif]

  5. XM_005201845.5 → XP_005201902.1  short transient receptor potential channel 1 isoform X1

    UniProtKB/TrEMBL
    A7VJS3
    Conserved Domains (3) summary
    cd00204
    Location:52 → 180
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:49 → 787
    trp; transient-receptor-potential calcium channel protein
    pfam08344
    Location:194 → 252
    TRP_2; Transient receptor ion channel II

  6. XM_059887336.1 → XP_059743319.1  short transient receptor potential channel 1 isoform X7

  7. XM_059887313.1 → XP_059743296.1  short transient receptor potential channel 1 isoform X7

  8. XM_059887367.1 → XP_059743350.1  short transient receptor potential channel 1 isoform X8

  9. XM_059887409.1 → XP_059743392.1  short transient receptor potential channel 1 isoform X9

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O18784.1 GenPept UniProtKB/Swiss-Prot:O18784

Gene LinkOut

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Molecular Biology Databases
Research Materials