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AKR1C4 aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4) [ Bos taurus (domestic cattle) ]

Gene ID: 282138, updated on 27-Dec-2024

Summary

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Gene symbol
AKR1C4
Gene description
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
See related
BGD:BT23296; Ensembl:ENSBTAG00000058245
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
AKR1C1
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Genomic context

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See AKR1C4 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (43616999..43626832)

Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) Neighboring gene uncharacterized LOC107131369 Neighboring gene aldo-keto reductase family 1 member C3 -like Neighboring gene dihydrodiol dehydrogenase 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. cDNA cloning, expression, and mutagenesis study of liver-type prostaglandin F synthase. Suzuki T, et al. J Biol Chem, 1999 Jan 1. PMID 9867836
  2. Structural similarity of bovine lung prostaglandin F synthase to lens epsilon-crystallin of the European common frog. Watanabe K, et al. Proc Natl Acad Sci U S A, 1988 Jan. PMID 2829166, Free PMC Article
  3. A lung type prostaglandin F synthase is expressed in bovine liver: cDNA sequence and expression in E. coli. Kuchinke W, et al. Biochem Biophys Res Commun, 1992 Mar 31. PMID 1339268
  4. An aldose reductase with 20 alpha-hydroxysteroid dehydrogenase activity is most likely the enzyme responsible for the production of prostaglandin f2 alpha in the bovine endometrium. Madore E, et al. J Biol Chem, 2003 Mar 28. PMID 12551929
  5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC137190

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables aldose reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables androsterone dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables bile acid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ketosteroid monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in daunorubicin metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in doxorubicin metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in progesterone metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in prostaglandin metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
dihydrodiol dehydrogenase 3
Names
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
prostaglandin F synthase
NP_851370.1
XP_005214492.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181027.2 → NP_851370.1  dihydrodiol dehydrogenase 3

    See identical proteins and their annotated locations for NP_851370.1

    Status: PROVISIONAL

    Source sequence(s)
    D49542
    UniProtKB/Swiss-Prot
    P52898, Q2KIT3
    UniProtKB/TrEMBL
    M0QW14
    Related
    ENSBTAP00000014044.2, ENSBTAT00000014044.4
    Conserved Domains (2) summary
    COG0656
    Location:7 → 300
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:16 → 297
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    43616999..43626832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005214435.5 → XP_005214492.1  dihydrodiol dehydrogenase 3 isoform X1

    UniProtKB/TrEMBL
    M0QW14
    Conserved Domains (1) summary
    COG0656
    Location:7 → 261
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]

RNA

  1. XR_009496774.1 RNA Sequence

    Related
    ENSBTAT00000134009.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52898.1 GenPept UniProtKB/Swiss-Prot:P52898

Gene LinkOut

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