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ATP2B4 ATPase plasma membrane Ca2+ transporting 4 [ Bos taurus (domestic cattle) ]

Gene ID: 282146, updated on 1-Jan-2025

Summary

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Official Symbol
ATP2B4provided by VGNC
Official Full Name
ATPase plasma membrane Ca2+ transporting 4provided by VGNC
Primary source
VGNC:VGNC:97243
See related
BGD:BT21263; Ensembl:ENSBTAG00000014059
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
PMCA4
Orthologs
human mouse all
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Genomic context

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See ATP2B4 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 16 NC_037343.1 (1398257..1500871)

Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112441938 Neighboring gene proline and arginine rich end leucine rich repeat protein Neighboring gene opticin Neighboring gene uncharacterized LOC132342430 Neighboring gene lymphocyte transmembrane adaptor 1 Neighboring gene uncharacterized LOC132342431 Neighboring gene zinc finger CCCH-type containing 11A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Switch of PMCA4 splice variants in bovine epididymis results in altered isoform expression during functional sperm maturation. Brandenburger T, et al. J Biol Chem, 2011 Mar 11. PMID 21187283, Free PMC Article
  2. The missing link between thermodynamics and structure in F1-ATPase. Yang W, et al. Proc Natl Acad Sci U S A, 2003 Feb 4. PMID 12552084, Free PMC Article
  3. Arrangement of PMCA4 in bovine sperm membrane fractions. Post H, et al. Int J Androl, 2010 Dec. PMID 20050939
  4. A C-terminal, calmodulin-like regulatory domain from the plasma membrane Ca2+-pumping ATPase. Brandt P, et al. Proc Natl Acad Sci U S A, 1988 May. PMID 2966397, Free PMC Article
  5. Analysis of the tissue-specific distribution of mRNAs encoding the plasma membrane calcium-pumping ATPases and characterization of an alternately spliced form of PMCA4 at the cDNA and genomic levels. Brandt P, et al. J Biol Chem, 1992 Mar 5. PMID 1531651

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Switch of PMCA4 splice variants in bovine epididymis results in altered isoform expression during functional sperm maturation.
    Title: Switch of PMCA4 splice variants in bovine epididymis results in altered isoform expression during functional sperm maturation.
  2. results indicate possible functional compartmentalization of PMCA in bull sperm membranes and point to a presumptive, interaction partner of Ca(2+)-ATPase and PDC-109.
    Title: Arrangement of PMCA4 in bovine sperm membrane fractions.
  3. thermodynamic analysis of mitochondrial F1 ATPase
    Title: The missing link between thermodynamics and structure in F1-ATPase.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables P-type calcium transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables PDZ domain binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
plasma membrane calcium-transporting ATPase 4
Names
ATPase, Ca++ transporting, plasma membrane 4 ATP synthase, H+ transporting, mitochondrial F1
NP_001166065.1
XP_024831809.1
XP_024831810.1
XP_024831814.1
XP_024831815.1
XP_024831817.1
XP_024831819.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172594.1 → NP_001166065.1  plasma membrane calcium-transporting ATPase 4

    See identical proteins and their annotated locations for NP_001166065.1

    Status: PROVISIONAL

    Source sequence(s)
    GU353069
    UniProtKB/TrEMBL
    F1MQ01
    Related
    ENSBTAP00000018688.7, ENSBTAT00000018688.7
    Conserved Domains (7) summary
    TIGR01517
    Location:20 → 1040
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam00122
    Location:159 → 442
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:856 → 1034
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:47 → 111
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12424
    Location:1077 → 1139
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    pfam12710
    Location:643 → 782
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:503 → 592
    Cation_ATPase; Cation transport ATPase (P-type)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    1398257..1500871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024976047.2 → XP_024831815.1  plasma membrane calcium-transporting ATPase 4 isoform X3

    UniProtKB/TrEMBL
    F1MQ01
    Conserved Domains (2) summary
    pfam12424
    Location:1089 → 1150
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    cl27747
    Location:20 → 1052
    E1-E2_ATPase; E1-E2 ATPase

  2. XM_024976051.2 → XP_024831819.1  plasma membrane calcium-transporting ATPase 4 isoform X5

    UniProtKB/TrEMBL
    F1MQ01
    Conserved Domains (2) summary
    pfam12424
    Location:1089 → 1171
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    cl27747
    Location:20 → 1052
    E1-E2_ATPase; E1-E2 ATPase

  3. XM_024976041.2 → XP_024831809.1  plasma membrane calcium-transporting ATPase 4 isoform X1

    UniProtKB/Swiss-Prot
    D3K0R5, D3K0R6, Q28059
    UniProtKB/TrEMBL
    F1MQ01
    Conserved Domains (2) summary
    pfam12424
    Location:1089 → 1135
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    cl27747
    Location:20 → 1052
    E1-E2_ATPase; E1-E2 ATPase

  4. XM_024976049.2 → XP_024831817.1  plasma membrane calcium-transporting ATPase 4 isoform X4

    UniProtKB/TrEMBL
    F1MQ01
    Conserved Domains (2) summary
    pfam12424
    Location:1077 → 1138
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    cl27747
    Location:20 → 1040
    E1-E2_ATPase; E1-E2 ATPase

  5. XM_024976046.2 → XP_024831814.1  plasma membrane calcium-transporting ATPase 4 isoform X2

    UniProtKB/TrEMBL
    A0AAF6ZTI3, F1MQ01
    Related
    ENSBTAP00000057551.2, ENSBTAT00000071315.2
    Conserved Domains (2) summary
    pfam12424
    Location:1077 → 1123
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    cl27747
    Location:20 → 1040
    E1-E2_ATPase; E1-E2 ATPase

  6. XM_024976042.2 → XP_024831810.1  plasma membrane calcium-transporting ATPase 4 isoform X1

    UniProtKB/Swiss-Prot
    D3K0R5, D3K0R6, Q28059
    UniProtKB/TrEMBL
    F1MQ01
    Related
    ENSBTAP00000063820.2, ENSBTAT00000079645.2
    Conserved Domains (2) summary
    pfam12424
    Location:1089 → 1135
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    cl27747
    Location:20 → 1052
    E1-E2_ATPase; E1-E2 ATPase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3K0R6.2 GenPept UniProtKB/Swiss-Prot:D3K0R6

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