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SLCO1A2 solute carrier organic anion transporter family member 1A2 [ Bos taurus (domestic cattle) ]

Gene ID: 282472, updated on 30-Jan-2025

Summary

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Official Symbol
SLCO1A2provided by VGNC
Official Full Name
solute carrier organic anion transporter family member 1A2provided by VGNC
Primary source
VGNC:VGNC:34949
See related
BGD:BT18198; EnsemblRapid:ENSBTAG00070025884
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
SLC21A3
Orthologs
human all
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Genomic context

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See SLCO1A2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (88777624..88890682)

Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene RecQ like helicase Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 1 Neighboring gene islet amyloid polypeptide Neighboring gene solute carrier organic anion transporter family member 1B3 Neighboring gene heme-binding protein 1 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Identification of multiple binding sites for substrate transport in bovine organic anion transporting polypeptide 1a2. Liu X, et al. Drug Metab Dispos, 2013 Mar. PMID 23255551
  2. Molecular cloning and functional characterization of the bovine (Bos taurus) organic anion transporting polypeptide Oatp1a2 (Slco1a2). Geyer J, et al. Comp Biochem Physiol B Biochem Mol Biol, 2004 Mar. PMID 15050519
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Demonstrate two binding sites of bOatp1a2 for estrone-3-sulfate in HEK293 cell system.
    Title: Identification of multiple binding sites for substrate transport in bovine organic anion transporting polypeptide 1a2.
  2. based on the tested substrates bovine Oatp1a2 shows functional homology to human OATP1A2
    Title: Molecular cloning and functional characterization of the bovine (Bos taurus) organic anion transporting polypeptide Oatp1a2 (Slco1a2).
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables bile acid transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables sodium-independent organic anion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in bile acid and bile salt transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sodium-independent organic anion transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
solute carrier organic anion transporter family member 1A2
Names
organic anion transporting polypeptide 1a2
organic anion transporting polypeptide A
solute carrier family 21 (organic anion transporter), member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174654.2 → NP_777079.1  solute carrier organic anion transporter family member 1A2

    See identical proteins and their annotated locations for NP_777079.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ508718
    UniProtKB/TrEMBL
    A0A3Q1N7T3, Q95KY9
    Related
    ENSBTAP00070034847.1, ENSBTAT00070058625.1
    Conserved Domains (3) summary
    cd06174
    Location:23 → 379
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:432 → 485
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    TIGR00805
    Location:1 → 622
    oat; sodium-independent organic anion transporter

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    88777624..88890682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024991375.2 → XP_024847143.1  solute carrier organic anion transporter family member 1A2 isoform X1

    UniProtKB/TrEMBL
    A0A3Q1N7T3, A2VDW7
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 622
    oat; sodium-independent organic anion transporter

  2. XM_059886122.1 → XP_059742105.1  solute carrier organic anion transporter family member 1A2 isoform X1

    UniProtKB/TrEMBL
    A0A3Q1N7T3, A2VDW7

  3. XM_010805398.4 → XP_010803700.1  solute carrier organic anion transporter family member 1A2 isoform X1

    See identical proteins and their annotated locations for XP_010803700.1

    UniProtKB/TrEMBL
    A0A3Q1N7T3, A2VDW7
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 622
    oat; sodium-independent organic anion transporter
Nucleotide Protein Strain
Heading Accession and Version

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