TNFRSF1A TNF receptor superfamily member 1A [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: TNFRSF1Aprovided by VGNC
Official Full Name: TNF receptor superfamily member 1Aprovided by VGNC
Primary source: VGNC:VGNC:36164
See related: BGD:BT10161; Ensembl:ENSBTAG00000004211
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	5	NC_037332.1 (104024027..104036846)

Chromosome 5 - NC_037332.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that TNF-alpha sources include immune cells, as well as large and small luteal cells, and that TNF-RI and TNF-RII are present in the luteal cells of the bovine corpus luteum.
Title: Localization of gene and protein expressions of tumor necrosis factor-{alpha} and tumor necrosis factor receptor types I and II in the bovine corpus luteum during the estrous cycle.
The expression and cellular localization of tumor necrosis factor-alpha (TNF) and its receptors (TNFRI and TNFRII) mRNAs and proteins, were determined.
Title: Cellular localization of genes and proteins for tumor necrosis factor-α (TNF), TNF receptor types I and II in bovine endometrium.
The upregulation of TNFRI mRNA expression by IFNG suggests that TNF and IFNG synergistically affect the death of luteal endothelial cells resulting in acute luteolysis
Title: Effects of tumor necrosis factor α and Interferon γ on the viability and mRNA expression of TNF receptor type I in endothelial cells from the bovine corpus luteum.
TNF binding induces release of AIP1 (DAB2IP) from TNFR1, resulting in cytoplasmic translocation and concomitant formation of an intracellular signaling complex comprised of TRADD, RIP1, TRAF2, and AIPl.
Title: AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables tumor necrosis factor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables tumor necrosis factor receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in prostaglandin metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane raft	IEA Inferred from Electronic Annotation more info	PubMed
part_of receptor complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 1A

Names: TNF-R1; TNF-RI; TNFR-I; p55; p60; tumor necrosis factor receptor 1; tumor necrosis factor receptor superfamily, member 1A; tumor necrosis factor receptor type I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174674.2 → NP_777099.1 tumor necrosis factor receptor superfamily member 1A precursor

See identical proteins and their annotated locations for NP_777099.1

Status: PROVISIONAL

Source sequence(s)

U90937

UniProtKB/Swiss-Prot

O19131, Q2HJ72

UniProtKB/TrEMBL

F1MSX5

Related

ENSBTAP00070037522.1, ENSBTAT00070062678.1

Conserved Domains (2) summary

cd08313
Location:374 → 454

Death_TNFR1; Death domain of Tumor Necrosis Factor Receptor 1

cd10576
Location:44 → 175

TNFRSF1A; Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), also known as TNFR1