Fbln2 fibulin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fbln2provided by RGD
Official Full Name: fibulin 2provided by RGD
Primary source: RGD:628685
See related: EnsemblRapid:ENSRNOG00000007338 AllianceGenome:RGD:628685
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable extracellular matrix binding activity. Predicted to be involved in positive regulation of cell-substrate adhesion. Predicted to be located in extracellular region. Orthologous to human FBLN2 (fibulin 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Muscle (RPKM 187.5), Heart (RPKM 130.9) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (125261464..125321030)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (123704289..123763857)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (122835237..122895127)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fibulin-2 inhibition by siRNA abolishes TGF-beta1 neurogenic effect.
Title: Fibulin-2 is a key mediator of the pro-neurogenic effect of TGF-beta1 on adult neural stem cells.
Study identified and validated a novel bona fide target of miR-1, Fibullin-2 (Fbln2), a secreted protein implicated in extracellular matrix remodeling.
Title: Therapeutic cardiac-targeted delivery of miR-1 reverses pressure overload-induced cardiac hypertrophy and attenuates pathological remodeling.
fibulin-1 and -2 respond differentially to single and repeated damaging noxae, and their expression is differently present in liver cells
Title: Expression of ECM proteins fibulin-1 and -2 in acute and chronic liver disease and in cultured rat liver cells.

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General gene information

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Markers

RH128760 (e-PCR)
- UniSTS:212068

D4Rat183 (e-PCR), detects polymorphism
- UniSTS:227742

UniSTS:235496 (e-PCR)
- UniSTS:235496

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables extracellular matrix binding	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular matrix binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of cell-substrate adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell-substrate adhesion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fibulin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100490.1 → NP_001093960.1 fibulin-2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A6IB94, G3V6X1

Related

ENSRNOP00000009696.6, ENSRNOT00000009696.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

125261464..125321030

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006236924.4 → XP_006236986.1 fibulin-2 isoform X1

See identical proteins and their annotated locations for XP_006236986.1

UniProtKB/TrEMBL

A0A8I6A720, A6IB95

Related

ENSRNOP00000086234.1, ENSRNOT00000115833.2

Conserved Domains (7) summary

smart00179
Location:848 → 890

EGF_CA; Calcium-binding EGF-like domain

cd00017
Location:428 → 479

ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...

pfam07645
Location:754 → 798

EGF_CA; Calcium-binding EGF domain

pfam12662
Location:952 → 975

cEGF; Complement Clr-like EGF-like

pfam14670
Location:903 → 931

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00032
Location:505 → 553

ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...

cl21504
Location:709 → 745

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...