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AQP1 aquaporin 1 [ Bos taurus (domestic cattle) ]

Gene ID: 282653, updated on 1-Jan-2025

Summary

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Official Symbol
AQP1provided by VGNC
Official Full Name
aquaporin 1provided by VGNC
Primary source
VGNC:VGNC:107216
See related
BGD:BT20336
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
AQP-1; CHIP29
Orthologs
human mouse all
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Genomic context

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See AQP1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (65433647..65447845, complement)

Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene ADCYAP receptor type I Neighboring gene uncharacterized LOC112446389 Neighboring gene growth hormone releasing hormone receptor Neighboring gene oxysterol-binding protein-related protein 9-like Neighboring gene MINDY lysine 48 deubiquitinase 4 Neighboring gene indolethylamine N-methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Crystallization and preliminary X-ray crystallographic analysis of water channel AQP1. Sui H, et al. Acta Crystallogr D Biol Crystallogr, 2000 Sep. PMID 10957645
  2. Cloning of a novel cDNA homologous to CHIP28 water channel from ocular ciliary epithelium. Patil RV, et al. Biochem Biophys Res Commun, 1994 Oct 28. PMID 7526855
  3. Aquaporin-1 facilitates pressure-driven water flow across the aortic endothelium. Nguyen T, et al. Am J Physiol Heart Circ Physiol, 2015 May 1. PMID 25659484, Free PMC Article
  4. Dynamic and energetic mechanisms for the distinct permeation rate in AQP1 and AQP0. Qiu H, et al. Biochim Biophys Acta, 2010 Mar. PMID 19961829
  5. The structure of the aquaporin-1 water channel: a comparison between cryo-electron microscopy and X-ray crystallography. de Groot BL, et al. J Mol Biol, 2003 Jan 17. PMID 12498798

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Aquaporin-1 significantly contributes to hydrostatic pressure-driven water transport across aortic endothelial monolayers in culture.
    Title: Aquaporin-1 facilitates pressure-driven water flow across the aortic endothelium.
  2. Comparisons of free-energy and interaction-energy profiles for water conduction between AQP0 and AQP1 indicate that this interruption of the water chain causes a huge energy barrier opposing water translocation through AQP0.
    Title: Dynamic and energetic mechanisms for the distinct permeation rate in AQP1 and AQP0.
  3. Data present a detailed comparison between the cryo-electron microscopy and X-ray crystallography model structures of the human and bovine water channel aquaporin-1 (AQP1).
    Title: The structure of the aquaporin-1 water channel: a comparison between cryo-electron microscopy and X-ray crystallography.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC129064

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ammonium channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables carbon dioxide transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables glycerol transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables water channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbon dioxide transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hyperosmotic response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in renal water transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
aquaporin-1
Names
aquaporin 1 (Colton blood group)
aquaporin-CHIP
water channel protein CHIP29
water channel protein for red blood cells and kidney proximal tubule
NP_777127.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174702.3 → NP_777127.1  aquaporin-1

    Status: PROVISIONAL

    Source sequence(s)
    BC105525
    UniProtKB/Swiss-Prot
    P47865, Q2HJE2
    Conserved Domains (1) summary
    pfam00230
    Location:4 → 229
    MIP; Major intrinsic protein

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    65433647..65447845 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47865.3 GenPept UniProtKB/Swiss-Prot:P47865

Gene LinkOut

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