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MYH7 myosin heavy chain 7 [ Bos taurus (domestic cattle) ]

Gene ID: 282714, updated on 1-Jan-2025

Summary

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Gene symbol
MYH7
Gene description
myosin heavy chain 7
See related
BGD:BT17484; Ensembl:ENSBTAG00000009703
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
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Genomic context

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See MYH7 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (21488782..21510518)

Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene zinc finger homeobox 2 Neighboring gene neuroguidin Neighboring gene microRNA mir-208b Neighboring gene myosin heavy chain 6 Neighboring gene microRNA mir-208a Neighboring gene CKLF like MARVEL transmembrane domain containing 5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Myosin heavy chain isoforms expressed in bovine skeletal muscles. Chikuni K, et al. Meat Sci, 2004 May. PMID 22061120
  2. Sequencing of the 2a, 2x, and slow isoforms of the bovine myosin heavy chain and the different expression among muscles. Tanabe R, et al. Mamm Genome, 1998 Dec. PMID 9880677
  3. Temperature-dependence of isometric tension and cross-bridge kinetics of cardiac muscle fibers reconstituted with a tropomyosin internal deletion mutant. Lu X, et al. Biophys J, 2006 Dec 1. PMID 16980359, Free PMC Article
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tm affects the conformation of actin so as to increase the area of hydrophobic interaction between actin and myosin molecules
    Title: Temperature-dependence of isometric tension and cross-bridge kinetics of cardiac muscle fibers reconstituted with a tropomyosin internal deletion mutant.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables microfilament motor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adult heart development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cardiac muscle contraction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in muscle filament sliding IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sarcomere organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of myosin II complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in myosin filament IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
myosin-7
Names
myHC-beta
myHC-slow
myosin, heavy polypeptide 7, cardiac muscle, beta
type slow/beta myosin heavy chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174727.1 → NP_777152.1  myosin-7

    See identical proteins and their annotated locations for NP_777152.1

    Status: PROVISIONAL

    Source sequence(s)
    AB059400
    UniProtKB/Swiss-Prot
    Q9BE39
    UniProtKB/TrEMBL
    F1N2G0
    Related
    ENSBTAP00000053217.3, ENSBTAT00000061306.3
    Conserved Domains (8) summary
    cd14917
    Location:99 → 766
    MYSc_Myh7; class II myosin heavy chain 7, motor domain
    pfam00063
    Location:87 → 766
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:846 → 1923
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:35 → 72
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam07851
    Location:1740 → 1830
    TMPIT; TMPIT-like protein
    cl00817
    Location:1132 → 1293
    MM_CoA_mutase; Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of ...
    cl02488
    Location:845 → 1041
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl12013
    Location:1232 → 1424
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    21488782..21510518
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024997290.2 → XP_024853058.1  myosin-7 isoform X1

    UniProtKB/TrEMBL
    F1MM07, F1N2G0
    Conserved Domains (3) summary
    cd14917
    Location:99 → 766
    MYSc_Myh7; class II myosin heavy chain 7, motor domain
    cl25732
    Location:1173 → 1930
    SMC_N; RecF/RecN/SMC N terminal domain
    cl27381
    Location:37 → 1432
    Myosin_head; Myosin head (motor domain)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BE39.1 GenPept UniProtKB/Swiss-Prot:Q9BE39

Gene LinkOut

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Molecular Biology Databases
Research Materials