U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CSNK2A3 casein kinase 2 alpha 3 [ Homo sapiens (human) ]

Gene ID: 283106, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
CSNK2A3provided by HGNC
Official Full Name
casein kinase 2 alpha 3provided by HGNC
Primary source
HGNC:HGNC:2458
See related
Ensembl:ENSG00000254598 AllianceGenome:HGNC:2458
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSNK2A1P
Summary
This gene encodes a protein that is highly similar to the casein kinase II alpha protein. Casein kinase II is a serine/threonine protein kinase complex that phosphorylates numerous substrates including casein. The alpha subunit is the catalytic component of the complex. Mutations in this gene may be associated with a susceptibility to lung cancer. There are contradictory views among published reports of this gene as to whether or not it is a protein-coding gene or a processed pseudogene (PMIDs: 20625391, 20625391 and 10094393). [provided by RefSeq, Feb 2012]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CSNK2A3 in Genome Data Viewer
Location:
11p15.4
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (11351942..11353250, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (11440863..11442171, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (11373489..11374797, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902631 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:11278996-11279162 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:11286683-11287184 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:11301387-11302362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:11312119-11312618 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 18 Neighboring gene uncharacterized LOC124902633 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:11400009-11400508 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:11425327-11426526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:11430413-11430914 Neighboring gene uncharacterized LOC107983976 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_18862 Neighboring gene NANOG hESC enhancer GRCh37_chr11:11530882-11531383 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:11559636-11560464 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_18916 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4454 Neighboring gene uncharacterized LOC124902632 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:11591851-11592350

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. CK2alpha loci in the human genome: structure and transcriptional activity. Wirkner U, et al. Mol Cell Biochem, 1999 Jan. PMID 10094393
  2. Human casein kinase II subunit alpha: sequence of a processed (pseudo)gene and its localization on chromosome 11. Wirkner U, et al. Biochim Biophys Acta, 1992 Jun 15. PMID 1610905
  3. Structure and sequence of an intronless gene for human casein kinase II-alpha subunit. Devilat I, et al. FEBS Lett, 1993 Jan 25. PMID 8420794
  4. Three-dimensional atomic structure of a catalytic subunit mutant of human protein kinase CK2. Pechkova E, et al. Acta Crystallogr D Biol Crystallogr, 2003 Dec. PMID 14646071
  5. Human casein kinase II: structures, genes, expression and requirement in cell growth stimulation. Pyerin W. Adv Enzyme Regul, 1994. PMID 7942276

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell growth IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein kinase CK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
casein kinase II subunit alpha 3
Names
CK II alpha 3
casein kinase 2, alpha 1 polypeptide pseudogene
casein kinase 2, alpha 3 polypeptide
casein kinase II alpha 1 polypeptide pseudogene
NP_001243615.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256686.2 → NP_001243615.1  casein kinase II subunit alpha 3

    See identical proteins and their annotated locations for NP_001243615.1

    Status: VALIDATED

    Source sequence(s)
    AC023946
    Consensus CDS
    CCDS59224.1
    UniProtKB/Swiss-Prot
    Q8NEV1
    UniProtKB/TrEMBL
    B2R6D7, B5BUH5
    Related
    ENSP00000473553.1, ENST00000528848.3
    Conserved Domains (3) summary
    cd14132
    Location:20 → 325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
    pfam00069
    Location:39 → 324
    Pkinase; Protein kinase domain
    pfam12484
    Location:332 → 389
    PE_PPE_C; Polymorphic PE/PPE proteins C terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    11351942..11353250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    11440863..11442171 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_002207.1: Suppressed sequence

    Description
    NR_002207.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NEV1.2 GenPept UniProtKB/Swiss-Prot:Q8NEV1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools