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micA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 2847697, updated on 3-Dec-2024

Summary

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Official Symbol
micA
Primary source
ECOCYC:G0-8866
Locus tag
b4442
See related
ASAP:ABE-0047262
Gene type
ncRNA
RNA name
other
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2682; psrA10; sraD
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Genomic context

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Sequence:
NC_000913.3 (2814802..2814874)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene multidrug efflux pump membrane subunit EmrB Neighboring gene S-ribosylhomocysteine lyase Neighboring gene glutamate--cysteine ligase Neighboring gene DedA family protein YqaA Neighboring gene fructose-1-phosphate phosphatase YqaB

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crucial roles of MicA and RybB as vital factors for σ-dependent cell lysis in Escherichia coli long-term stationary phase. Nagamitsu H, et al. J Mol Microbiol Biotechnol, 2013. PMID 23594456
  2. RfaH suppresses small RNA MicA inhibition of fimB expression in Escherichia coli K-12. Moores A, et al. J Bacteriol, 2014 Jan. PMID 24163336, Free PMC Article
  3. Novel pathway directed by σ E to cause cell lysis in Escherichia coli. Murata M, et al. Genes Cells, 2012 Mar. PMID 22251246
  4. MicA sRNA links the PhoP regulon to cell envelope stress. Coornaert A, et al. Mol Microbiol, 2010 Apr. PMID 20345657, Free PMC Article
  5. Hfq-dependent regulation of OmpA synthesis is mediated by an antisense RNA. Udekwu KI, et al. Genes Dev, 2005 Oct 1. PMID 16204185, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PNPase and RNase PH facilitate the stability and regulatory function of the sRNAs RyhB, CyaR, and MicA during exponential growth.
    Title: The Phosphorolytic Exoribonucleases Polynucleotide Phosphorylase and RNase PH Stabilize sRNAs and Facilitate Regulation of Their mRNA Targets.
  2. These results demonstrate a complex role for RfaH as a regulator of fimB expression via the suppression micA non-coding RNA.
    Title: RfaH suppresses small RNA MicA inhibition of fimB expression in Escherichia coli K-12.
  3. Crucial roles of MicA and RybB as vital factors for sigma-dependent cell lysis in Escherichia coli long-term stationary phase.
    Title: Crucial roles of MicA and RybB as vital factors for σ-dependent cell lysis in Escherichia coli long-term stationary phase.
  4. Taken together, the results suggest that the cell lysis proceeds in the cascade of sigma(E) --> expression of micA and rybB --> reduction in Omp proteins --> disintegration of the outer membrane.
    Title: Novel pathway directed by σ E to cause cell lysis in Escherichia coli.
  5. MicA directly pairs with phoPQ mRNA in the translation initiation region of phoP and presumably inhibits translation by competing with ribosome binding.
    Title: MicA sRNA links the PhoP regulon to cell envelope stress.
  6. The antisense RNA MicA (previously named SraD) is part of the sigma(E) regulon and downregulates its target gene, ompA, probably to alleviate membrane stress.
    Title: Sigma E controls biogenesis of the antisense RNA MicA.
Submit: New GeneRIF Correction

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