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MROCKI MARCKS cis regulating lncRNA promoter of cytokines and inflammation [ Homo sapiens (human) ]

Gene ID: 285758, updated on 22-Oct-2024

Summary

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Official Symbol
MROCKIprovided by HGNC
Official Full Name
MARCKS cis regulating lncRNA promoter of cytokines and inflammationprovided by HGNC
Primary source
HGNC:HGNC:50323
See related
Ensembl:ENSG00000227502 AllianceGenome:HGNC:50323
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ROCKI; LINC01268
Expression
Broad expression in small intestine (RPKM 2.4), duodenum (RPKM 1.9) and 17 other tissues See more
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Genomic context

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Location:
6q21
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (113868013..113873347, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (115052224..115057552, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (114189178..114194512, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901547 Neighboring gene Sharpr-MPRA regulatory region 13716 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24972 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:114177679-114178224 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:114178225-114178768 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17487 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:114180401-114180944 Neighboring gene myristoylated alanine rich protein kinase C substrate Neighboring gene uncharacterized LOC124901382 Neighboring gene long intergenic non-protein coding RNA 2880

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [Effect of Long Non-Coding RNA LINC01268 on the Malignant Biological Behaviors of Acute Myeloid Leukemia Cells]. Chen W, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2023 Dec. PMID 38071035
  2. Association of a Noncoding RNA Postmortem With Suicide by Violent Means and In Vivo With Aggressive Phenotypes. Punzi G, et al. Biol Psychiatry, 2019 Mar 1. PMID 30600091
  3. Expression of LOC285758, a Potential Long Non-coding Biomarker, is Methylation-dependent and Correlates with Glioma Malignancy Grade. Matjasic A, et al. Radiol Oncol, 2017 Sep. PMID 28959170, Free PMC Article
  4. Increased expression of MARCKS in post-mortem brain of violent suicide completers is related to transcription of a long, noncoding, antisense RNA. Punzi G, et al. Mol Psychiatry, 2014 Oct. PMID 24821221
  5. The long noncoding RNA ROCKI regulates inflammatory gene expression. Zhang Q, et al. EMBO J, 2019 Apr 15. PMID 30918008, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. [Effect of Long Non-Coding RNA LINC01268 on the Malignant Biological Behaviors of Acute Myeloid Leukemia Cells].
    Title: [Effect of Long Non-Coding RNA LINC01268 on the Malignant Biological Behaviors of Acute Myeloid Leukemia Cells].
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • long intergenic non-protein coding RNA 1268
  • regulator of cytokines and inflammation

Clone Names

  • FLJ14368

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_038863.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BC037331, FO393415
    Related
    ENST00000434296.3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    113868013..113873347 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    115052224..115057552 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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