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sqst-5 ZZ-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 28661656, updated on 4-Jan-2025

Summary

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Official Symbol
sqst-5
Official Full Name
ZZ-type domain-containing protein
Primary source
WormBase:WBGene00269434
Locus tag
CELE_T17A3.13
See related
AllianceGenome:WB:WBGene00269434
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and protein kinase C binding activity. Predicted to be involved in aggrephagy; endosome organization; and mitophagy. Predicted to be active in aggresome and amphisome. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See sqst-5 in Genome Data Viewer
Location:
chromosome: III
Exon count:
2
Sequence:
Chromosome: III; NC_003281.10 (146969..147620, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene F-box associated domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene F-box domain-containing protein Neighboring gene pseudo Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Natural variation in the sequestosome-related gene, sqst-5, underlies zinc homeostasis in Caenorhabditis elegans. Evans KS, et al. PLoS Genet, 2020 Nov. PMID 33175833, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Natural variation in the sequestosome-related gene, sqst-5, underlies zinc homeostasis in Caenorhabditis elegans.
    Title: Natural variation in the sequestosome-related gene, sqst-5, underlies zinc homeostasis in Caenorhabditis elegans.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase C binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aggrephagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in aggresome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in amphisome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ZZ-type domain-containing protein
NP_497158.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    146969..147620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064757.8 → NP_497158.3  ZZ-type domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A168H2N7
    Conserved Domains (1) summary
    cd02340
    Location:126 → 167
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
Nucleotide Protein
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