ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: ADAMTS4provided by VGNC
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif 4provided by VGNC
Primary source: VGNC:VGNC:25627
See related: Ensembl:ENSBTAG00000013210
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	3	NC_037330.1 (8303802..8311858)

Chromosome 3 - NC_037330.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ADAMTS4 participates in the regulation of muscle development in cattle.
Title: Expression of ADAMTS4 and ADAMTS5 in longissimus dorsi muscle related to meat tenderness in Nanyang cattle.
aggrecanase activity (a) is responsible for early TNFalpha-dependent aggrecan cleavage and GAG release in the meniscus and (b) might be involved in meniscal degeneration.
Title: Tumor necrosis factor alpha-dependent aggrecan cleavage and release of glycosaminoglycans in the meniscus is mediated by nitrous oxide-independent aggrecanase activity in vitro.
identified multiple conserved amino acids within regions N- and C-terminal to the site of scission that may influence enzyme-substrate recognition, and may interact with exosites on ADAMTS-4 and ADAMTS-5
Title: Conserved sequence in the aggrecan interglobular domain modulates cleavage by ADAMTS-4 and ADAMTS-5.
ADAMTS4 and ADAMTS5 are inhibited by alpha2-macroglobulin
Title: Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes.

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General gene information

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Markers

AU048745 (e-PCR)
- UniSTS:145195

ADAMST4 (e-PCR), detects polymorphism
- UniSTS:279437

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs 4

Names: ADAM-TS 4; ADAM-TS4; ADAMTS-4; ADMP-1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4; aggrecanase-1

NP_858053.1

EC 3.4.24.82

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181667.1 → NP_858053.1 A disintegrin and metalloproteinase with thrombospondin motifs 4 precursor

See identical proteins and their annotated locations for NP_858053.1

Status: PROVISIONAL

Source sequence(s)

AF516915

UniProtKB/Swiss-Prot

A6QLR5, Q7YS95, Q9TT93

Related

ENSBTAP00000017583.5, ENSBTAT00000017583.6

Conserved Domains (6) summary

smart00209
Location:531 → 575

TSP1; Thrombospondin type 1 repeats

cd04273
Location:218 → 425

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01421
Location:218 → 428

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:78 → 181

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:687 → 803

ADAM_spacer1; ADAM-TS Spacer 1

cl15456
Location:438 → 509

ADAM_CR; ADAM cysteine-rich