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SHH sonic hedgehog signaling molecule [ Bos taurus (domestic cattle) ]

Gene ID: 286821, updated on 30-Jan-2025

Summary

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Official Symbol
SHHprovided by VGNC
Official Full Name
sonic hedgehog signaling moleculeprovided by VGNC
Primary source
VGNC:VGNC:34597
See related
BGD:BT24488; EnsemblRapid:ENSBTAG00070018111
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See SHH in Genome Data Viewer
Location:
chromosome: 4
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (117483495..117495745, complement)

Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene transfer RNA glycine (anticodon GCC) Neighboring gene RNA binding motif protein 33 Neighboring gene uncharacterized LOC112446461 Neighboring gene uncharacterized LOC132345160 Neighboring gene ring finger protein 32

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Copy number variation of bovine SHH gene is associated with body conformation traits in Chinese beef cattle. Liu M, et al. J Appl Genet, 2019 May. PMID 30997664
  2. Sonic Hedgehog, a key development gene, experienced intensified molecular evolution in primates. Dorus S, et al. Hum Mol Genet, 2006 Jul 1. PMID 16687440
  3. Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs. Lopez-Rios J, et al. Nature, 2014 Jul 3. PMID 24990743
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results revealed that the copy number gain type of SHH-CNV exhibited significantly better chest depth in 24 months old Qinchuan cattle, and better body weight, body length, and chest girth in 18 months old Nanyang cattle, whereas the normal copy number had superior chest girth and body weight in adult Jinnan cattle..this research uncovered meaningful effects of SHH-CNV on gene expression and cattle phenotypic traits
    Title: Copy number variation of bovine SHH gene is associated with body conformation traits in Chinese beef cattle.
  2. study shows evolutionary alteration of a Ptch1 cis-regulatory module, which no longer responds to graded SHH signalling during bovine handplate development
    Title: Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables patched binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell fate specification IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-cell signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intein-mediated protein splicing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein autoprocessing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
sonic hedgehog protein
Names
sonic hedgehog homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    117483495..117495745 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024991301.2 → XP_024847069.1  sonic hedgehog protein

    UniProtKB/TrEMBL
    F1MM97
    Related
    ENSBTAP00070024344.1, ENSBTAT00070040861.1
    Conserved Domains (2) summary
    pfam01079
    Location:190 → 450
    Hint; Hint module
    pfam01085
    Location:42 → 187
    HH_signal; Hedgehog amino-terminal signalling domain
Nucleotide Protein Strain
Heading Accession and Version

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Molecular Biology Databases
Research Materials