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Np4 defensin NP-4 precursor [ Rattus norvegicus (Norway rat) ]

Gene ID: 286958, updated on 27-Nov-2024

Summary

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Official Symbol
Np4provided by RGD
Official Full Name
defensin NP-4 precursorprovided by RGD
Primary source
RGD:727857
See related
EnsemblRapid:ENSRNOG00000069755 AllianceGenome:RGD:727857
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
NP-4
Summary
Predicted to enable protein homodimerization activity. Predicted to be involved in several processes, including T cell chemotaxis; cellular response to lipopolysaccharide; and defense response to other organism. Predicted to be located in azurophil granule. Predicted to be active in extracellular space. Orthologous to several human genes including DEFA5 (defensin alpha 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 485.6) See more
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Genomic context

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See Np4 in Genome Data Viewer
Location:
16q12.5
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (77197061..77199713, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (70494607..70497261, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (75478548..75481146, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene defensin alpha 5, pseudogene 1 Neighboring gene defensin alpha 9 Neighboring gene defensin alpha 31 Neighboring gene defensin alpha 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family. Wilde CG, et al. J Biol Chem, 1989 Jul 5. PMID 2500436
  2. Rat neutrophil defensins. Precursor structures and expression during neutrophilic myelopoiesis. Yount NY, et al. J Immunol, 1995 Nov 1. PMID 7594610
  3. Purification and antimicrobial properties of three defensins from rat neutrophils. Eisenhauer PB, et al. Infect Immun, 1989 Jul. PMID 2543629, Free PMC Article
  4. Increased diversity of intestinal antimicrobial peptides by covalent dimer formation. Hornef MW, et al. Nat Immunol, 2004 Aug. PMID 15235601
  5. Antibacterial activity and specificity of the six human {alpha}-defensins. Ericksen B, et al. Antimicrob Agents Chemother, 2005 Jan. PMID 15616305, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in T cell chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in antibacterial humoral response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response TAS
Traceable Author Statement
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to bacterium IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to fungus IEA
Inferred from Electronic Annotation
more info
  
involved_in disruption of plasma membrane integrity in another organism IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response in mucosa IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in killing of cells of another organism IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in azurophil granule ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
defensin alpha 4
Names
defensin 3b
neutrophil antibiotic peptide NP-4
neutrophil defensin 4
ratNP-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173299.3 → NP_775421.1  defensin alpha 4 precursor

    See identical proteins and their annotated locations for NP_775421.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/Swiss-Prot
    Q62714
    UniProtKB/TrEMBL
    A6IW99
    Related
    ENSRNOP00000098273.1, ENSRNOT00000120638.2
    Conserved Domains (2) summary
    pfam00323
    Location:64 → 92
    Defensin_1; Mammalian defensin
    pfam00879
    Location:16 → 50
    Defensin_propep; Defensin propeptide

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    77197061..77199713 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253366.4 → XP_006253428.1  defensin alpha 4 isoform X1

    UniProtKB/TrEMBL
    A0A8L2QLB0
    Conserved Domains (2) summary
    pfam00323
    Location:97 → 125
    Defensin_1; Mammalian defensin
    pfam00879
    Location:49 → 83
    Defensin_propep; Defensin propeptide
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62714.1 GenPept UniProtKB/Swiss-Prot:Q62714

Gene LinkOut

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