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Cyp2d5 cytochrome P450, family 2, subfamily d, polypeptide 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 286963, updated on 4-Jan-2025

Summary

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Official Symbol
Cyp2d5provided by RGD
Official Full Name
cytochrome P450, family 2, subfamily d, polypeptide 5provided by RGD
Primary source
RGD:628630
See related
EnsemblRapid:ENSRNOG00000077236 AllianceGenome:RGD:628630
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cyp2d10
Summary
Predicted to enable heme binding activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Predicted to be involved in arachidonate metabolic process and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; extrapyramidal and movement disease; head and neck squamous cell carcinoma; leukemia (multiple); and major depressive disorder. Orthologous to human CYP2D6 (cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)) and CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward (RPKM 1419.8) See more
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Genomic context

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See Cyp2d5 in Genome Data Viewer
Location:
7q34
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (115779981..115784554, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (113899905..113904458, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (123616596..123621102, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit A6 Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 4 Neighboring gene uncharacterized LOC103692951 Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 1 Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cytochrome P450CMF cDNA: nucleotide sequence of P450CMF1b. Ishida N, et al. Nucleic Acids Res, 1989 Aug 11. PMID 2771656, Free PMC Article
  2. Four species of cDNAs for cytochrome P450 isozymes immunorelated to P450C-M/F encode for members of P450IID subfamily, increasing the number of members within the subfamily. Ishida N, et al. Biochem Biophys Res Commun, 1988 Oct 31. PMID 3190674
  3. The CYP2D gene subfamily: analysis of the molecular basis of the debrisoquine 4-hydroxylase deficiency in DA rats. Matsunaga E, et al. Biochemistry, 1989 Sep 5. PMID 2819073
  4. The rat P450 IID subfamily: complete sequences of four closely linked genes and evidence that gene conversions maintained sequence homogeneity at the heme-binding region of the cytochrome P450 active site. Matsunaga E, et al. J Mol Evol, 1990 Feb. PMID 2107330
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC108540

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity TAS
Traceable Author Statement
more info
 PubMed 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in arachidonate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytochrome P450 2D10
Names
CYPIID10
P450-CMF1B
P450-DB5
cytochrome P450, family 2, subfamily d, polypeptide 10
cytochrome P450-CMF1B
cytochrome P450-DB5
cytochrome P450CMF1b
debrisoquine 4-hydroxylase
NP_775426.1
XP_038934457.1
XP_038934458.1
XP_038934459.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173304.2 → NP_775426.1  cytochrome P450 2D10

    See identical proteins and their annotated locations for NP_775426.1

    Status: PROVISIONAL

    Source sequence(s)
    J02869
    UniProtKB/Swiss-Prot
    P12939
    UniProtKB/TrEMBL
    F7FD56, Q5I0P9
    Related
    ENSRNOP00000040266.2, ENSRNOT00000046024.5
    Conserved Domains (1) summary
    pfam00067
    Location:37 → 496
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    115779981..115784554 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078529.2 → XP_038934457.1  cytochrome P450 2D10 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GJ89, F7FD56, Q5I0P9
    Related
    ENSRNOP00000091804.1, ENSRNOT00000095995.2
    Conserved Domains (1) summary
    cl41757
    Location:68 → 444
    cytochrome_P450; cytochrome P450 (CYP) superfamily

  2. XM_039078530.2 → XP_038934458.1  cytochrome P450 2D10 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZWE8
    Related
    ENSRNOP00000100990.1, ENSRNOT00000151808.1
    Conserved Domains (1) summary
    cl41757
    Location:68 → 385
    cytochrome_P450; cytochrome P450 (CYP) superfamily

  3. XM_039078531.2 → XP_038934459.1  cytochrome P450 2D10 isoform X3

    Conserved Domains (2) summary
    cl12078
    Location:9 → 97
    p450; Cytochrome P450
    cl41757
    Location:68 → 289
    cytochrome_P450; cytochrome P450 (CYP) superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P12939.1 GenPept UniProtKB/Swiss-Prot:P12939

Gene LinkOut

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