Tox4 TOX high mobility group box family member 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tox4provided by RGD
Official Full Name: TOX high mobility group box family member 4provided by RGD
Primary source: RGD:708449
See related: EnsemblRapid:ENSRNOG00000012844 AllianceGenome:RGD:708449
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD708449
Summary: Predicted to enable chromatin DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromatin and chromosome, telomeric region. Predicted to be part of PTW/PP1 phosphatase complex. Predicted to be active in nucleus. Orthologous to human TOX4 (TOX high mobility group box family member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 171.7), Testes (RPKM 153.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p14

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (27462735..27476320)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (24989246..25002833)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (28696378..28709960)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI236262 (e-PCR)
- UniSTS:250490

RH140974 (e-PCR)
- UniSTS:222975

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of PTW/PP1 phosphatase complex	IEA Inferred from Electronic Annotation more info
part_of PTW/PP1 phosphatase complex	ISO Inferred from Sequence Orthology more info
part_of PTW/PP1 phosphatase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: TOX high mobility group box family member 4

Names: epidermal Langerhans cell protein LCP1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173324.2 → NP_775446.2 TOX high mobility group box family member 4

See identical proteins and their annotated locations for NP_775446.2

Status: PROVISIONAL

Source sequence(s)

BC081696

UniProtKB/Swiss-Prot

Q99PM1

UniProtKB/TrEMBL

A6KEH2, F7EPW2, Q66HT2

Related

ENSRNOP00000017476.5, ENSRNOT00000017476.9

Conserved Domains (3) summary

PHA03160
Location:464 → 530

PHA03160; hypothetical protein; Provisional

COG5648
Location:140 → 306

NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]

cd00084
Location:223 → 288

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...