Mapk15 mitogen-activated protein kinase 15 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mapk15provided by RGD
Official Full Name: mitogen-activated protein kinase 15provided by RGD
Primary source: RGD:628675
See related: EnsemblRapid:ENSRNOG00000009336 AllianceGenome:RGD:628675
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Erk7; ERK-8
Summary: Predicted to enable MAP kinase activity and chromatin binding activity. Involved in several processes, including negative regulation of nucleobase-containing compound metabolic process; positive regulation of protein metabolic process; and response to estradiol. Located in nucleus. Orthologous to human MAPK15 (mitogen-activated protein kinase 15). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 39.2), Lung (RPKM 17.6) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (109575619..109595339)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (107694907..107714640)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (117041287..117061799)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	ISO Inferred from Sequence Orthology more info
enables MAP kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables kinase activity	ISO Inferred from Sequence Orthology more info
enables kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in dopamine uptake	IEA Inferred from Electronic Annotation more info
involved_in dopamine uptake	ISO Inferred from Sequence Orthology more info
involved_in dopamine uptake	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoplasmic reticulum organization	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum organization	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of metaphase/anaphase transition of meiosis I	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of metaphase/anaphase transition of meiosis I	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of spindle assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomere maintenance	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of telomere maintenance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to ciliary transition zone	IEA Inferred from Electronic Annotation more info
involved_in protein localization to ciliary transition zone	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of COPII vesicle coating	IEA Inferred from Electronic Annotation more info
involved_in regulation of COPII vesicle coating	ISO Inferred from Sequence Orthology more info
involved_in regulation of COPII vesicle coating	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of autophagy	IEA Inferred from Electronic Annotation more info
involved_in regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in regulation of autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to estradiol	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in autophagosome	IEA Inferred from Electronic Annotation more info
located_in autophagosome	ISO Inferred from Sequence Orthology more info
located_in autophagosome	ISS Inferred from Sequence or Structural Similarity more info
NOT located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISS Inferred from Sequence or Structural Similarity more info
located_in centriole	IEA Inferred from Electronic Annotation more info
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in centriole	ISS Inferred from Sequence or Structural Similarity more info
located_in ciliary basal body	IEA Inferred from Electronic Annotation more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in meiotic spindle	IEA Inferred from Electronic Annotation more info
located_in meiotic spindle	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitogen-activated protein kinase 15

Names: ERK-7; MAP kinase 15; MAPK 15; extracellular signal-regulated kinase 7; extracellular signal-regulated kinase 8

NP_775453.1

EC 2.7.11.24

XP_006241841.1

EC 2.7.11.24

XP_038934462.1

EC 2.7.11.24

XP_038934463.1

EC 2.7.11.24

XP_038934465.1

EC 2.7.11.24

XP_038934466.1

EC 2.7.11.24

XP_063119153.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173331.2 → NP_775453.1 mitogen-activated protein kinase 15

See identical proteins and their annotated locations for NP_775453.1

Status: VALIDATED

Source sequence(s)

AF078798

UniProtKB/Swiss-Prot

Q9Z2A6

UniProtKB/TrEMBL

A0A8I6A4Q6, A6HS47

Conserved Domains (1) summary

cd07852
Location:6 → 344

STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

109575619..109595339

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063263083.1 → XP_063119153.1 mitogen-activated protein kinase 15 isoform X1

UniProtKB/TrEMBL

A0A0G2KAB2
XM_006241779.5 → XP_006241841.1 mitogen-activated protein kinase 15 isoform X2

See identical proteins and their annotated locations for XP_006241841.1

UniProtKB/Swiss-Prot

Q9Z2A6

UniProtKB/TrEMBL

A0A8I6A4Q6, A6HS47

Related

ENSRNOP00000012460.3, ENSRNOT00000012461.6

Conserved Domains (1) summary

cd07852
Location:6 → 344

STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
XM_039078534.2 → XP_038934462.1 mitogen-activated protein kinase 15 isoform X3

UniProtKB/TrEMBL

A0A8I6A4Q6

Conserved Domains (1) summary

cd07852
Location:6 → 344

STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
XM_039078535.2 → XP_038934463.1 mitogen-activated protein kinase 15 isoform X4

Conserved Domains (1) summary

cd07852
Location:6 → 344

STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
XM_039078537.2 → XP_038934465.1 mitogen-activated protein kinase 15 isoform X5

Conserved Domains (1) summary

cl21453
Location:6 → 275

PKc_like; Protein Kinases, catalytic domain
XM_039078538.2 → XP_038934466.1 mitogen-activated protein kinase 15 isoform X6

Conserved Domains (1) summary

cl21453
Location:6 → 265

PKc_like; Protein Kinases, catalytic domain