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Zfp263 zinc finger protein 263 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287076, updated on 4-Jan-2025

Summary

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Official Symbol
Zfp263provided by RGD
Official Full Name
zinc finger protein 263provided by RGD
Primary source
RGD:1307301
See related
EnsemblRapid:ENSRNOG00000007678 AllianceGenome:RGD:1307301
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZNF263 (zinc finger protein 263). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 52.6), Thymus (RPKM 45.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zfp263 in Genome Data Viewer
Location:
10q12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (12270785..12280982, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (11764424..11774324, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (12023677..12035189, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480755 Neighboring gene uncharacterized LOC134480757 Neighboring gene uncharacterized LOC102551940 Neighboring gene uncharacterized LOC134480756 Neighboring gene MEFV innate immunity regulator, pyrin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Genomic targets of the KRAB and SCAN domain-containing zinc finger protein 263. Frietze S, et al. J Biol Chem, 2010 Jan 8. PMID 19887448, Free PMC Article
  2. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Yin Y, et al. Science, 2017 May 5. PMID 28473536, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 263

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399418.1 → NP_001386347.1  zinc finger protein 263

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    D3ZQ68
    Related
    ENSRNOP00000010442.6, ENSRNOT00000010442.8
    Conserved Domains (5) summary
    smart00431
    Location:41 → 151
    SCAN; leucine rich region
    COG5048
    Location:460 → 646
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:436 → 456
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:645 → 667
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:219 → 257
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    12270785..12280982 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006245831.5 → XP_006245893.1  zinc finger protein 263 isoform X1

    UniProtKB/TrEMBL
    A6K4V1
    Conserved Domains (7) summary
    cd07765
    Location:134 → 172
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:135 → 193
    KRAB; krueppel associated box
    COG5048
    Location:375 → 561
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:351 → 371
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:349 → 371
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:41 → 127
    SCAN; SCAN domain
    pfam13465
    Location:391 → 416
    zf-H2C2_2; Zinc-finger double domain

  2. XM_063268528.1 → XP_063124598.1  zinc finger protein 263 isoform X2

    UniProtKB/TrEMBL
    A6K4V2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001105763.1: Suppressed sequence

    Description
    NM_001105763.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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