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Rnps1 RNA binding protein with serine rich domain 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287113, updated on 4-Jan-2025

Summary

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Official Symbol
Rnps1provided by RGD
Official Full Name
RNA binding protein with serine rich domain 1provided by RGD
Primary source
RGD:1307522
See related
EnsemblRapid:ENSRNOG00000008703 AllianceGenome:RGD:1307522
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in mRNA metabolic process; positive regulation of apoptotic process; and regulation of mRNA splicing, via spliceosome. Predicted to be located in nucleus. Predicted to be part of ASAP complex. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human RNPS1 (RNA binding protein with serine rich domain 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 459.8), Spleen (RPKM 322.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rnps1 in Genome Data Viewer
Location:
10q12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (13950151..13960396)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13445516..13455858)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (13786339..13796720)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, subfamily A (ABC1), member 17 Neighboring gene uncharacterized LOC134480760 Neighboring gene ATP binding cassette subfamily A member 3 Neighboring gene uncharacterized LOC120095048 Neighboring gene enoyl-CoA delta isomerase 1 Neighboring gene deoxyribonuclease 1 like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The ever-increasing complexities of the exon junction complex. Tange TØ, et al. Curr Opin Cell Biol, 2004 Jun. PMID 15145352
  2. ASAP, a novel protein complex involved in RNA processing and apoptosis. Schwerk C, et al. Mol Cell Biol, 2003 Apr. PMID 12665594, Free PMC Article
  3. Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators. Michelle L, et al. Mol Cell Biol, 2012 Mar. PMID 22203037, Free PMC Article
  4. The structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complex. Murachelli AG, et al. Nat Struct Mol Biol, 2012 Mar 4. PMID 22388736
  5. Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1. Lykke-Andersen J, et al. Science, 2001 Sep 7. PMID 11546874

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of ASAP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ASAP complex ISO
Inferred from Sequence Orthology
more info
  
part_of ASAP complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RNA-binding protein with serine-rich domain 1
Names
RNA binding protein S1
ribonucleic acid binding protein S1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011890.1 → NP_001011890.1  RNA-binding protein with serine-rich domain 1

    See identical proteins and their annotated locations for NP_001011890.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079014
    UniProtKB/Swiss-Prot
    Q6AYK1
    UniProtKB/TrEMBL
    A0A8L2QN59, A6HCR9
    Related
    ENSRNOP00000085374.2, ENSRNOT00000100575.2
    Conserved Domains (1) summary
    cd12365
    Location:163 → 236
    RRM_RNPS1; RNA recognition motif (RRM) found in RNA-binding protein with serine-rich domain 1 (RNPS1) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    13950151..13960396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006245933.4 → XP_006245995.1  RNA-binding protein with serine-rich domain 1 isoform X1

    See identical proteins and their annotated locations for XP_006245995.1

    UniProtKB/TrEMBL
    A0A8I6AKA2
    Related
    ENSRNOP00000090425.2, ENSRNOT00000106045.2
    Conserved Domains (1) summary
    cd12365
    Location:140 → 213
    RRM_RNPS1; RNA recognition motif (RRM) found in RNA-binding protein with serine-rich domain 1 (RNPS1) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AYK1.1 GenPept UniProtKB/Swiss-Prot:Q6AYK1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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