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MIR166a [ Arabidopsis thaliana (thale cress) ]

Gene ID: 28718357, updated on 11-Sep-2024

Summary

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Official Symbol
MIR166a
Primary source
TAIR:AT2G46685
Locus tag
AT2G46685
See related
Araport:AT2G46685
Gene type
ncRNA
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
MICRORNA 166; microRNA166A; MIR166; MIR166A; p_MI0000201
Summary
Encodes a microRNA that targets several HD-ZIPIII family members including PHV, PHB, REV, ATHB-8, and ATHB-15. This particular miRNA is involved in the regulation of vascular development in inflorescence stems, primarily through the regulation of mRNA cleavage of the class III homeodomain-leucine zipper transcription factor ATHB15. MicroRNAs are regulatory RNAs with a mature length of ~21-nucleotides that are processed from hairpin precursors by Dicer-like enzymes. MicroRNAs can negatively regulate gene expression by attenuating translation or by directing mRNA cleavage.Mature sequence: UCGGACCAGGCUUCAUUCCCC. Pri-mRNA coordinates for MIR166a (converted to TAIR10 based on PMID19304749): Chr2: 19175959-19177071 (forward), length: 1113 bp; exon coordinates: exon 1: 19175959 to 19176341, exon 2: 19176820 to 19177071; mature miRNA and miRNA* are located on exon 1.
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Genomic context

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See MIR166a in Genome Data Viewer
Location:
chromosome: 2
Exon count:
1
Sequence:
Chromosome: 2; NC_003071.7 (19176108..19176277)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene CCT motif family protein Neighboring gene homeobox 7 Neighboring gene ncRNA Neighboring gene SAUR-like auxin-responsive protein family

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. microRNA-directed cleavage of ATHB15 mRNA regulates vascular development in Arabidopsis inflorescence stems. Kim J, et al. Plant J, 2005 Apr. PMID 15773855, Free PMC Article
  2. Dose-Dependent AGO1-Mediated Inhibition of the miRNA165/166 Pathway Modulates Stem Cell Maintenance in Arabidopsis Shoot Apical Meristem. Du F, et al. Plant Commun, 2020 Jan 13. PMID 33404539, Free PMC Article
  3. The interaction between miR160 and miR165/166 in the control of leaf development and drought tolerance in Arabidopsis. Yang T, et al. Sci Rep, 2019 Feb 26. PMID 30808969, Free PMC Article
  4. ARGONAUTE10 Inhibits In Vitro Shoot Regeneration Via Repression of miR165/166 in Arabidopsis thaliana. Xue T, et al. Plant Cell Physiol, 2017 Oct 1. PMID 29016889
  5. ARGONAUTE10 promotes the degradation of miR165/6 through the SDN1 and SDN2 exonucleases in Arabidopsis. Yu Y, et al. PLoS Biol, 2017 Feb. PMID 28231321, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dose-Dependent AGO1-Mediated Inhibition of the miRNA165/166 Pathway Modulates Stem Cell Maintenance in Arabidopsis Shoot Apical Meristem.
    Title: Dose-Dependent AGO1-Mediated Inhibition of the miRNA165/166 Pathway Modulates Stem Cell Maintenance in Arabidopsis Shoot Apical Meristem.
  2. The interaction between miR160 and miR165/166 in the control of leaf development and drought tolerance in Arabidopsis.
    Title: The interaction between miR160 and miR165/166 in the control of leaf development and drought tolerance in Arabidopsis.
  3. the shoot regeneration inhibition determined by AGO10 functions via the repression of miR165/166.
    Title: ARGONAUTE10 Inhibits In Vitro Shoot Regeneration Via Repression of miR165/166 in Arabidopsis thaliana.
  4. AGO10 reduces miR165/6 accumulation by enhancing its degradation by SDN1 and SDN2 in vivo.
    Title: ARGONAUTE10 promotes the degradation of miR165/6 through the SDN1 and SDN2 exonucleases in Arabidopsis.
Submit: New GeneRIF Correction

General gene information

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  • mature miRNA accession:MIMAT0000189
  • mature miRNA accession:MIMAT0031880

Gene Ontology Provided by TAIR

Process Evidence Code Pubs
acts_upstream_of_or_within miRNA-mediated gene silencing by mRNA destabilization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within phloem or xylem histogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    19176108..19176277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. NR_140787.1 RNA Sequence

    Status: REVIEWED

Gene LinkOut

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Molecular Biology Databases
Research Materials