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Ttc1 tetratricopeptide repeat domain 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287208, updated on 27-Nov-2024

Summary

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Official Symbol
Ttc1provided by RGD
Official Full Name
tetratricopeptide repeat domain 1provided by RGD
Primary source
RGD:1359604
See related
EnsemblRapid:ENSRNOG00000003980 AllianceGenome:RGD:1359604
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be located in cytosol. Orthologous to human TTC1 (tetratricopeptide repeat domain 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 199.2), Heart (RPKM 182.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ttc1 in Genome Data Viewer
Location:
10q21
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (28703763..28728910, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (28202325..28227464, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (29342495..29367865, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2, pseudogene 35 Neighboring gene PWWP domain containing 2A Neighboring gene uncharacterized LOC108352076 Neighboring gene adrenoceptor alpha 1B Neighboring gene uncharacterized LOC134480677

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras. Marty C, et al. Mol Cell Biol, 2003 Jun. PMID 12748287, Free PMC Article
  2. A direct interaction between cytoplasmic dynein and kinesin I may coordinate motor activity. Ligon LA, et al. J Biol Chem, 2004 Apr 30. PMID 14985359
  3. PEX14 is required for microtubule-based peroxisome motility in human cells. Bharti P, et al. J Cell Sci, 2011 May 15. PMID 21525035
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC95276

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tetratricopeptide repeat protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005529.1 → NP_001005529.1  tetratricopeptide repeat protein 1

    See identical proteins and their annotated locations for NP_001005529.1

    Status: PROVISIONAL

    Source sequence(s)
    BC082093
    UniProtKB/TrEMBL
    A0A8I6AEL9, F7ER79, Q66H09
    Related
    ENSRNOP00000005304.3, ENSRNOT00000005304.7
    Conserved Domains (4) summary
    sd00006
    Location:119 → 144
    TPR; TPR repeat [structural motif]
    cd15830
    Location:126 → 244
    BamD; BamD lipoprotein, a component of the beta-barrel assembly machinery
    pfam00515
    Location:158 → 188
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:119 → 186
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    28703763..28728910 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085372.2 → XP_038941300.1  tetratricopeptide repeat protein 1 isoform X1

    Conserved Domains (2) summary
    TIGR00990
    Location:116 → 212
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:119 → 144
    TPR; TPR repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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