Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acap1provided by RGD
Official Full Name: ArfGAP with coiled-coil, ankyrin repeat and PH domains 1provided by RGD
Primary source: RGD:1305360
See related: EnsemblRapid:ENSRNOG00000015674 AllianceGenome:RGD:1305360
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Centb1
Summary: Predicted to enable GTPase activator activity and metal ion binding activity. Predicted to be located in endosome membrane. Orthologous to human ACAP1 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Thymus (RPKM 750.8), Spleen (RPKM 335.4) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (55104040..55119280, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (54605323..54619472, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (56492300..56506446, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endosome membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1

Names: centaurin, beta 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105796.2 → NP_001099266.2 arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I5ZQC3, D4ABD3

Related

ENSRNOP00000021357.4, ENSRNOT00000021357.8

Conserved Domains (7) summary

cd07639
Location:18 → 217

BAR_ACAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 1

cd00204
Location:592 → 692

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd13250
Location:268 → 364

PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain

pfam00169
Location:266 → 360

PH; PH domain

pfam01412
Location:406 → 519

ArfGap; Putative GTPase activating protein for Arf

pfam13857
Location:626 → 680

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:575 → 602

ANK; ANK repeat [structural motif]