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Elp5 elongator acetyltransferase complex subunit 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287446, updated on 14-Nov-2024

Summary

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Official Symbol
Elp5provided by RGD
Official Full Name
elongator acetyltransferase complex subunit 5provided by RGD
Primary source
RGD:1303303
See related
EnsemblRapid:ENSRNOG00000027628 AllianceGenome:RGD:1303303
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
DERP6; Rai12
Summary
Predicted to contribute to tRNA binding activity. Predicted to be involved in positive regulation of cell migration and tRNA modification. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of elongator holoenzyme complex. Predicted to be active in cytosol and nucleus. Orthologous to human ELP5 (elongator acetyltransferase complex subunit 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 79.4), Adrenal (RPKM 78.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Elp5 in Genome Data Viewer
Location:
10q24
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55191223..55202949, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54692526..54704255, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56578980..56590706, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene cofilin-1-like Neighboring gene claudin 7 Neighboring gene CTD nuclear envelope phosphatase 1 Neighboring gene GABA type A receptor-associated protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator. Close P, et al. J Biol Chem, 2012 Sep 21. PMID 22854966, Free PMC Article
  2. Association of connexin43 with E3 ubiquitin ligase TRIM21 reveals a mechanism for gap junction phosphodegron control. Chen VC, et al. J Proteome Res, 2012 Dec 7. PMID 23106098
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tRNA modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA wobble uridine modification IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of elongator holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of elongator holoenzyme complex IEA
Inferred from Electronic Annotation
more info
  
part_of elongator holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  
part_of elongator holoenzyme complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
elongator complex protein 5
Names
S-phase 2 protein
dermal papilla derived protein 6
dermal papilla-derived protein 6 homolog
retinoic acid induced 12
retinoic acid-induced protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001718.1 → NP_001001718.1  elongator complex protein 5

    See identical proteins and their annotated locations for NP_001001718.1

    Status: PROVISIONAL

    Source sequence(s)
    AY623900
    UniProtKB/Swiss-Prot
    Q6IUP3
    UniProtKB/TrEMBL
    A6HFY9
    Conserved Domains (1) summary
    cd19496
    Location:30 → 192
    Elp5; Elongator subcomplex subunit Elp5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    55191223..55202949 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597092.1 → XP_017452581.1  elongator complex protein 5 isoform X1

    UniProtKB/TrEMBL
    B0BMU7
    Related
    ENSRNOP00000035345.5, ENSRNOT00000032481.7
    Conserved Domains (1) summary
    pfam10483
    Location:19 → 302
    Elong_Iki1; Elongator subunit Iki1

  2. XM_063268644.1 → XP_063124714.1  elongator complex protein 5 isoform X3

    UniProtKB/TrEMBL
    A6HFZ1

  3. XM_039085463.2 → XP_038941391.1  elongator complex protein 5 isoform X2

    Conserved Domains (1) summary
    cd19496
    Location:30 → 160
    Elp5; Elongator subcomplex subunit Elp5

RNA

  1. XR_005489736.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IUP3.1 GenPept UniProtKB/Swiss-Prot:Q6IUP3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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