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Tex14 testis expressed 14, intercellular bridge forming factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 287603, updated on 4-Jan-2025

Summary

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Official Symbol
Tex14provided by RGD
Official Full Name
testis expressed 14, intercellular bridge forming factorprovided by RGD
Primary source
RGD:1305437
See related
EnsemblRapid:ENSRNOG00000023698 AllianceGenome:RGD:1305437
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein kinase binding activity. Predicted to be involved in several processes, including intercellular bridge organization; mitotic spindle assembly checkpoint signaling; and nuclear chromosome segregation. Predicted to act upstream of or within cellular response to leukemia inhibitory factor and negative regulation of cytokinesis. Predicted to be located in cytoplasm. Predicted to be active in intercellular bridge; kinetochore; and midbody. Human ortholog(s) of this gene implicated in spermatogenic failure 23. Orthologous to human TEX14 (testis expressed 14, intercellular bridge forming factor). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Testes (RPKM 114.1) and Kidney (RPKM 13.5) See more
Orthologs
human mouse all
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Genomic context

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See Tex14 in Genome Data Viewer
Location:
10q26
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (72729017..72859697)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (72231766..72356938)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (74724070..74849172)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480845 Neighboring gene RAD51 paralog C Neighboring gene uncharacterized LOC134480851 Neighboring gene U1 spliceosomal RNA Neighboring gene uncharacterized LOC134480849 Neighboring gene transfer RNA asparagine (anticodon GUU) 9 Neighboring gene U1 spliceosomal RNA Neighboring gene uncharacterized LOC134480850 Neighboring gene small nucleolar RNA U3 Neighboring gene U4 spliceosomal RNA Neighboring gene small nucleolar RNA U3 Neighboring gene zinc finger protein OZF-like Neighboring gene small nucleolar RNA U3 Neighboring gene uncharacterized LOC134480848 Neighboring gene septin 4 Neighboring gene myotubularin related protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Conversion of midbodies into germ cell intercellular bridges. Greenbaum MP, et al. Dev Biol, 2007 May 15. PMID 17383626, Free PMC Article
  2. TEX14 is essential for intercellular bridges and fertility in male mice. Greenbaum MP, et al. Proc Natl Acad Sci U S A, 2006 Mar 28. PMID 16549803, Free PMC Article
  3. Tex14, a Plk1-regulated protein, is required for kinetochore-microtubule attachment and regulation of the spindle assembly checkpoint. Mondal G, et al. Mol Cell, 2012 Mar 9. PMID 22405274, Free PMC Article
  4. TEX14 interacts with CEP55 to block cell abscission. Iwamori T, et al. Mol Cell Biol, 2010 May. PMID 20176808, Free PMC Article
  5. Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. Kang D, et al. J Proteome Res, 2008 Aug. PMID 18570454

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in attachment of spindle microtubules to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in attachment of spindle microtubules to kinetochore IEA
Inferred from Electronic Annotation
more info
  
involved_in attachment of spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
  
involved_in attachment of spindle microtubules to kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
  
involved_in intercellular bridge organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intercellular bridge organization IEA
Inferred from Electronic Annotation
more info
  
involved_in intercellular bridge organization ISO
Inferred from Sequence Orthology
more info
  
involved_in intercellular bridge organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in male meiotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in male meiotic nuclear division IEA
Inferred from Electronic Annotation
more info
  
involved_in male meiotic nuclear division ISO
Inferred from Sequence Orthology
more info
  
involved_in male meiotic nuclear division ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic sister chromatid separation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic sister chromatid separation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic sister chromatid separation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic sister chromatid separation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic spindle assembly checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle assembly checkpoint signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cytokinesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in intercellular bridge IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intercellular bridge IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody IEA
Inferred from Electronic Annotation
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
inactive serine/threonine-protein kinase TEX14
Names
testis expressed gene 14
testis-expressed protein 14
testis-expressed sequence 14 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419556.1 → NP_001406485.1  inactive serine/threonine-protein kinase TEX14

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    F1M5M3
    Related
    ENSRNOP00000009077.8, ENSRNOT00000009077.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    72729017..72859697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039087362.2 → XP_038943290.1  inactive serine/threonine-protein kinase TEX14 isoform X1

    UniProtKB/Swiss-Prot
    F1M5M3
    Conserved Domains (4) summary
    PTZ00322
    Location:72 → 220
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    sd00045
    Location:27 → 53
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:27 → 119
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:270 → 507
    PKc_like; Protein Kinases, catalytic domain

  2. XM_039087366.2 → XP_038943294.1  inactive serine/threonine-protein kinase TEX14 isoform X5

    UniProtKB/Swiss-Prot
    F1M5M3
    Conserved Domains (4) summary
    PTZ00322
    Location:72 → 220
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    sd00045
    Location:27 → 53
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:27 → 119
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:270 → 507
    PKc_like; Protein Kinases, catalytic domain

  3. XM_039087365.2 → XP_038943293.1  inactive serine/threonine-protein kinase TEX14 isoform X3

    UniProtKB/Swiss-Prot
    F1M5M3
    Related
    ENSRNOP00000090596.2, ENSRNOT00000116997.2
    Conserved Domains (4) summary
    PTZ00322
    Location:72 → 220
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    sd00045
    Location:27 → 53
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:27 → 119
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:270 → 507
    PKc_like; Protein Kinases, catalytic domain

  4. XM_039087369.2 → XP_038943297.1  inactive serine/threonine-protein kinase TEX14 isoform X8

    UniProtKB/Swiss-Prot
    F1M5M3
    Conserved Domains (4) summary
    PTZ00322
    Location:72 → 220
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    sd00045
    Location:27 → 53
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:27 → 119
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:270 → 507
    PKc_like; Protein Kinases, catalytic domain

  5. XM_039087364.2 → XP_038943292.1  inactive serine/threonine-protein kinase TEX14 isoform X2

    UniProtKB/Swiss-Prot
    F1M5M3
    Conserved Domains (4) summary
    PTZ00322
    Location:72 → 220
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    sd00045
    Location:27 → 53
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:27 → 119
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:270 → 507
    PKc_like; Protein Kinases, catalytic domain

  6. XM_063268693.1 → XP_063124763.1  inactive serine/threonine-protein kinase TEX14 isoform X4

    UniProtKB/Swiss-Prot
    F1M5M3
    UniProtKB/TrEMBL
    A0A8I6ANJ7

  7. XM_039087370.2 → XP_038943298.1  inactive serine/threonine-protein kinase TEX14 isoform X9

    UniProtKB/TrEMBL
    J3KTR9
    Conserved Domains (4) summary
    PTZ00322
    Location:72 → 220
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    sd00045
    Location:27 → 53
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:27 → 119
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:270 → 507
    PKc_like; Protein Kinases, catalytic domain

  8. XM_039087371.2 → XP_038943299.1  inactive serine/threonine-protein kinase TEX14 isoform X10

    UniProtKB/TrEMBL
    J3KTR9
    Conserved Domains (4) summary
    PTZ00322
    Location:72 → 220
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    sd00045
    Location:27 → 53
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:27 → 119
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:270 → 507
    PKc_like; Protein Kinases, catalytic domain

  9. XM_063268694.1 → XP_063124764.1  inactive serine/threonine-protein kinase TEX14 isoform X11

    UniProtKB/TrEMBL
    J3KTR9

  10. XM_039087373.2 → XP_038943301.1  inactive serine/threonine-protein kinase TEX14 isoform X12

    Conserved Domains (4) summary
    PTZ00322
    Location:72 → 220
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    sd00045
    Location:27 → 53
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:27 → 119
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:270 → 507
    PKc_like; Protein Kinases, catalytic domain

  11. XM_039087363.2 → XP_038943291.1  inactive serine/threonine-protein kinase TEX14 isoform X1

    UniProtKB/Swiss-Prot
    F1M5M3
    Conserved Domains (4) summary
    PTZ00322
    Location:72 → 220
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    sd00045
    Location:27 → 53
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:27 → 119
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:270 → 507
    PKc_like; Protein Kinases, catalytic domain

  12. XM_039087368.2 → XP_038943296.1  inactive serine/threonine-protein kinase TEX14 isoform X7

    UniProtKB/Swiss-Prot
    F1M5M3
    Conserved Domains (4) summary
    PTZ00322
    Location:32 → 180
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    sd00045
    Location:15 → 46
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:18 → 61
    Ank_4; Ankyrin repeats (many copies)
    cl21453
    Location:230 → 467
    PKc_like; Protein Kinases, catalytic domain

  13. XM_039087367.2 → XP_038943295.1  inactive serine/threonine-protein kinase TEX14 isoform X6

    UniProtKB/Swiss-Prot
    F1M5M3
    Conserved Domains (4) summary
    PTZ00322
    Location:34 → 182
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    sd00045
    Location:17 → 48
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:20 → 63
    Ank_4; Ankyrin repeats (many copies)
    cl21453
    Location:232 → 469
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1M5M3.2 GenPept UniProtKB/Swiss-Prot:F1M5M3

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