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Vezf1 vascular endothelial zinc finger 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287615, updated on 27-Nov-2024

Summary

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Official Symbol
Vezf1provided by RGD
Official Full Name
vascular endothelial zinc finger 1provided by RGD
Primary source
RGD:1308058
See related
EnsemblRapid:ENSRNOG00000009819 AllianceGenome:RGD:1308058
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of endothelial cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within angiogenesis and endothelial cell development. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human VEZF1 (vascular endothelial zinc finger 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 248.4), Heart (RPKM 163.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Vezf1 in Genome Data Viewer
Location:
10q26
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (73341666..73373320)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (72859669..72876111)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (75365763..75382014)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor 1523 Neighboring gene uncharacterized LOC120095169 Neighboring gene dynein light chain LC8-type 2 Neighboring gene serine and arginine rich splicing factor 1 Neighboring gene CUE domain containing 1 Neighboring gene ribosomal protein L27a, pseudogene 10 Neighboring gene mitochondrial ribosomal protein S23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Vezf1/DB1 is an endothelial cell-specific transcription factor that regulates expression of the endothelin-1 promoter. Aitsebaomo J, et al. J Biol Chem, 2001 Oct 19. PMID 11504723
  2. Inhibition of microRNA-495 Enhances Therapeutic Angiogenesis of Human Induced Pluripotent Stem Cells. Liang J, et al. Stem Cells, 2017 Feb. PMID 27538588
  3. Dosage-dependent requirement for mouse Vezf1 in vascular system development. Kuhnert F, et al. Dev Biol, 2005 Jul 1. PMID 15882861, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within endothelial cell development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
vascular endothelial zinc finger 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304355.2 → NP_001291284.1  vascular endothelial zinc finger 1

    See identical proteins and their annotated locations for NP_001291284.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    F1M8R0
    Related
    ENSRNOP00000078894.2, ENSRNOT00000096619.2
    Conserved Domains (4) summary
    PRK12799
    Location:379 → 496
    motB; flagellar motor protein MotB; Reviewed
    COG5189
    Location:198 → 255
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:176 → 196
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:174 → 196
    zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    73341666..73373320
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063268707.1 → XP_063124777.1  vascular endothelial zinc finger 1 isoform X2

  2. XM_008768166.4 → XP_008766388.1  vascular endothelial zinc finger 1 isoform X1

    See identical proteins and their annotated locations for XP_008766388.1

    UniProtKB/TrEMBL
    A0A8I5ZLS0, F1M8R0
    Conserved Domains (4) summary
    PRK12799
    Location:385 → 502
    motB; flagellar motor protein MotB; Reviewed
    COG5189
    Location:198 → 255
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:176 → 196
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:174 → 196
    zf-C2H2; Zinc finger, C2H2 type

  3. XM_063268708.1 → XP_063124778.1  vascular endothelial zinc finger 1 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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