Dlx3 distal-less homeobox 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dlx3provided by RGD
Official Full Name: distal-less homeobox 3provided by RGD
Primary source: RGD:1304875
See related: EnsemblRapid:ENSRNOG00000004278 AllianceGenome:RGD:1304875
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; hair follicle cell proliferation; and hair follicle morphogenesis. Predicted to act upstream of or within several processes, including odontoblast differentiation; odontogenesis of dentin-containing tooth; and placenta development. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 4 and trichodontoosseous syndrome. Orthologous to human DLX3 (distal-less homeobox 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Muscle (RPKM 1.9), Lung (RPKM 1.3) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (80561335..80566730)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (80064489..80069891)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (82937971..82943367)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In conclusion, the changes in the expression of lncRNAs, mRNAs and proteins (Adamts7, P2ry6, Dlx3 and TP53) may possibly affect endometrial receptivity in rats with endometriosis during the implantation window, probably resulting in implantation failure of the embryo.
Title: lncRNA/mRNA profiling of endometriosis rat uterine tissues during the implantation window.
OA transcription is differentially regulated by Dlx3, Dlx5, and Msx2 during osteoblast differentiation.
Title: Homeodomain transcription factors regulate BMP-2-induced osteoactivin transcription in osteoblasts.
Results describe gene regulation by Dlx3 in relation to that of Msx2 and Dlx5 during osteoblast differentiation.
Title: Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene.

Submit: New GeneRIF Correction

General gene information

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Markers

PMC99823P1 (e-PCR)
- UniSTS:273687

Dlx3 (e-PCR), detects polymorphism
- UniSTS:506852

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel development	ISO Inferred from Sequence Orthology more info
involved_in embryonic skeletal system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in hair cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in hair cycle	ISO Inferred from Sequence Orthology more info
involved_in hair follicle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in hair follicle development	ISO Inferred from Sequence Orthology more info
involved_in hair follicle morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within odontoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in odontoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within placenta development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: homeobox protein DLX-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105832.1 → NP_001099302.1 homeobox protein DLX-3

See identical proteins and their annotated locations for NP_001099302.1

Status: PROVISIONAL

Source sequence(s)

CH473948

UniProtKB/TrEMBL

A6HI86, D4ADD0

Related

ENSRNOP00000005797.3, ENSRNOT00000005797.6

Conserved Domains (3) summary

COG5576
Location:109 → 230

COG5576; Homeodomain-containing transcription factor [Transcription]

pfam00046
Location:132 → 186

Homeobox; Homeobox domain

pfam12413
Location:27 → 107

DLL_N; Homeobox protein distal-less-like N terminal