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Fmnl1 formin-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287746, updated on 2-Nov-2024

Summary

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Official Symbol
Fmnl1provided by RGD
Official Full Name
formin-like 1provided by RGD
Primary source
RGD:1311042
See related
EnsemblRapid:ENSRNOG00000003207 AllianceGenome:RGD:1311042
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including GTPase activating protein binding activity; profilin binding activity; and small GTPase binding activity. Predicted to be involved in several processes, including actin filament severing; cortical actin cytoskeleton organization; and regulation of cell shape. Predicted to act upstream of or within substrate-dependent cell migration. Predicted to be located in phagocytic vesicle and plasma membrane. Predicted to be active in cytosol. Orthologous to human FMNL1 (formin like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 168.6), Thymus (RPKM 123.2) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fmnl1 in Genome Data Viewer
Location:
10q32.1
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (88615290..88643411)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (88115876..88143342)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (91253757..91281422)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene HEXIM P-TEFb complex subunit 1 Neighboring gene HEXIM P-TEFb complex subunit 2 Neighboring gene EF-hand calcium binding domain 15 Neighboring gene spermatogenesis associated 32 Neighboring gene uncharacterized LOC120095296 Neighboring gene mitogen-activated protein kinase kinase kinase 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages. Yayoshi-Yamamoto S, et al. Mol Cell Biol, 2000 Sep. PMID 10958683, Free PMC Article
  2. Bi-modal regulation of a formin by srGAP2. Mason FM, et al. J Biol Chem, 2011 Feb 25. PMID 21148482, Free PMC Article
  3. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. Bai SW, et al. BMC Biol, 2011 Aug 11. PMID 21834987, Free PMC Article
  4. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Buschow SI, et al. Immunol Cell Biol, 2010 Nov-Dec. PMID 20458337
  5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activating protein binding ISO
Inferred from Sequence Orthology
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
  
enables profilin binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin filament severing ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cortical actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cortical actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within substrate-dependent cell migration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
formin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105846.1 → NP_001099316.1  formin-like protein 1

    See identical proteins and their annotated locations for NP_001099316.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A6HJQ3, A6HJQ4, D3ZAZ1
    Related
    ENSRNOP00000062888.1, ENSRNOT00000065373.4
    Conserved Domains (3) summary
    pfam02181
    Location:572 → 937
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:233 → 406
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:28 → 154
    Drf_GBD; Diaphanous GTPase-binding Domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    88615290..88643411
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247499.5 → XP_006247561.1  formin-like protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZYX6
    Related
    ENSRNOP00000083255.2, ENSRNOT00000118615.2
    Conserved Domains (3) summary
    pfam02181
    Location:635 → 1000
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:289 → 469
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:28 → 286
    Drf_GBD; Diaphanous GTPase-binding Domain

  2. XM_006247498.5 → XP_006247560.1  formin-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYU6, A6HJQ3
    Conserved Domains (3) summary
    pfam02181
    Location:635 → 1000
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:289 → 469
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:28 → 286
    Drf_GBD; Diaphanous GTPase-binding Domain

  3. XM_063268750.1 → XP_063124820.1  formin-like protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8I6A0N3
    Related
    ENSRNOP00000084134.1, ENSRNOT00000110316.2

  4. XM_006247500.5 → XP_006247562.1  formin-like protein 1 isoform X3

    UniProtKB/TrEMBL
    A6HJQ3
    Related
    ENSRNOP00000070794.2, ENSRNOT00000087218.3
    Conserved Domains (3) summary
    pfam02181
    Location:629 → 994
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:283 → 463
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:28 → 280
    Drf_GBD; Diaphanous GTPase-binding Domain

  5. XM_008768266.4 → XP_008766488.1  formin-like protein 1 isoform X7

    UniProtKB/TrEMBL
    A6HJQ3
    Related
    ENSRNOP00000107106.1, ENSRNOT00000122620.1
    Conserved Domains (3) summary
    pfam02181
    Location:587 → 952
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:241 → 421
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:28 → 238
    Drf_GBD; Diaphanous GTPase-binding Domain

  6. XM_006247502.5 → XP_006247564.1  formin-like protein 1 isoform X4

    UniProtKB/TrEMBL
    A6HJQ3
    Conserved Domains (3) summary
    pfam02181
    Location:625 → 990
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:279 → 459
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:28 → 276
    Drf_GBD; Diaphanous GTPase-binding Domain

  7. XM_063268751.1 → XP_063124821.1  formin-like protein 1 isoform X6

  8. XM_008768267.4 → XP_008766489.1  formin-like protein 1 isoform X8

    UniProtKB/TrEMBL
    A6HJQ3
    Conserved Domains (3) summary
    pfam02181
    Location:577 → 942
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:231 → 411
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:28 → 228
    Drf_GBD; Diaphanous GTPase-binding Domain
Nucleotide Protein Strain
Heading Accession and Version

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