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Pycr1 pyrroline-5-carboxylate reductase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287877, updated on 27-Nov-2024

Summary

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Official Symbol
Pycr1provided by RGD
Official Full Name
pyrroline-5-carboxylate reductase 1provided by RGD
Primary source
RGD:1307863
See related
EnsemblRapid:ENSRNOG00000036682 AllianceGenome:RGD:1307863
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity and pyrroline-5-carboxylate reductase activity. Predicted to be involved in several processes, including L-proline biosynthetic process; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; and regulation of mitochondrial membrane potential. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIB and autosomal recessive cutis laxa type IIIB. Orthologous to human PYCR1 (pyrroline-5-carboxylate reductase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 41.3), Muscle (RPKM 21.8) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pycr1 in Genome Data Viewer
Location:
10q32.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (106416056..106420982, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (105917732..105922658, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (109817300..109822218, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene sirtuin 7 Neighboring gene MAF bZIP transcription factor G Neighboring gene myeloid-associated differentiation marker-like 2 Neighboring gene NOTUM, palmitoleoyl-protein carboxylesterase Neighboring gene ASPSCR1 tether for SLC2A4, UBX domain containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Crystal structure of human pyrroline-5-carboxylate reductase. Meng Z, et al. J Mol Biol, 2006 Jun 23. PMID 16730026
  2. Mutations in PYCR1 cause cutis laxa with progeroid features. Reversade B, et al. Nat Genet, 2009 Sep. PMID 19648921
  3. Purified human erythrocyte pyrroline-5-carboxylate reductase. Preferential oxidation of NADPH. Merrill MJ, et al. J Biol Chem, 1989 Jun 5. PMID 2722838
  4. Functional specialization in proline biosynthesis of melanoma. De Ingeniis J, et al. PLoS One, 2012. PMID 23024808, Free PMC Article
  5. DJ-1 cooperates with PYCR1 in cell protection against oxidative stress. Yasuda T, et al. Biochem Biophys Res Commun, 2013 Jun 28. PMID 23743200

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables pyrroline-5-carboxylate reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyrroline-5-carboxylate reductase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in L-proline biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-proline biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in proline biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pyrroline-5-carboxylate reductase 1, mitochondrial
NP_001099327.1
XP_008766694.1
XP_008766695.4
XP_008766696.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105857.3 → NP_001099327.1  pyrroline-5-carboxylate reductase 1, mitochondrial

    See identical proteins and their annotated locations for NP_001099327.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6AII4, A0A8I6GJW9, A6HLH3
    Related
    ENSRNOP00000093202.2, ENSRNOT00000110897.2
    Conserved Domains (1) summary
    PLN02688
    Location:1 → 268
    PLN02688; pyrroline-5-carboxylate reductase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    106416056..106420982 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008768472.3 → XP_008766694.1  pyrroline-5-carboxylate reductase 1, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0A8I6GJW9, D3ZXI0
    Conserved Domains (3) summary
    PLN02688
    Location:27 → 294
    PLN02688; pyrroline-5-carboxylate reductase
    pfam03807
    Location:30 → 124
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
    pfam14748
    Location:189 → 293
    P5CR_dimer; Pyrroline-5-carboxylate reductase dimerization

  2. XM_008768473.4 → XP_008766695.4  pyrroline-5-carboxylate reductase 1, mitochondrial isoform X1

    Related
    ENSRNOP00000106212.1, ENSRNOT00000122777.1

  3. XM_008768474.2 → XP_008766696.1  pyrroline-5-carboxylate reductase 1, mitochondrial isoform X3

    See identical proteins and their annotated locations for XP_008766696.1

    UniProtKB/TrEMBL
    A0A8I6GJW9
    Related
    ENSRNOP00000051832.5, ENSRNOT00000054949.6
    Conserved Domains (1) summary
    PLN02688
    Location:1 → 268
    PLN02688; pyrroline-5-carboxylate reductase
Nucleotide Protein Strain
Heading Accession and Version

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