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Zdhhc19 zinc finger DHHC-type palmitoyltransferase 19 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288045, updated on 4-Jan-2025

Summary

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Official Symbol
Zdhhc19provided by RGD
Official Full Name
zinc finger DHHC-type palmitoyltransferase 19provided by RGD
Primary source
RGD:1309014
See related
EnsemblRapid:ENSRNOG00000025055 AllianceGenome:RGD:1309014
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560310
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in peptidyl-L-cysteine S-palmitoylation; positive regulation of aggrephagy; and protein targeting to membrane. Predicted to be located in Golgi membrane and perinucleolar compartment. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC19 (zinc finger DHHC-type palmitoyltransferase 19). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Testes (RPKM 24.0), Heart (RPKM 12.6) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zdhhc19 in Genome Data Viewer
Location:
11q22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (81782899..81794105, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (68277847..68289110, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (71490346..71522959, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102547162 Neighboring gene uncharacterized LOC120095668 Neighboring gene solute carrier family 51 member A Neighboring gene uncharacterized LOC120095669 Neighboring gene phosphate cytidylyltransferase 1A, choline

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Palmitoylation of R-Ras by human DHHC19, a palmitoyl transferase with a CaaX box. Baumgart F, et al. Biochim Biophys Acta, 2010 Mar. PMID 20074548
  2. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. Ohno Y, et al. Biochim Biophys Acta, 2006 Apr. PMID 16647879
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC156468

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in peptidyl-L-cysteine S-palmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of aggrephagy ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in perinucleolar compartment ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC19
Names
membrane-associated DHHC19 zinc finger protein
probable palmitoyltransferase ZDHHC19
zinc finger, DHHC domain containing 19
zinc finger, DHHC-type containing 19
NP_001034348.1
XP_006248509.1
XP_038944044.1
XP_038944045.1
XP_063126445.1
XP_063126446.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039259.2 → NP_001034348.1  palmitoyltransferase ZDHHC19

    See identical proteins and their annotated locations for NP_001034348.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    Q2TGJ0
    Related
    ENSRNOP00000038846.4, ENSRNOT00000033026.8
    Conserved Domains (1) summary
    pfam01529
    Location:112 → 230
    zf-DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    81782899..81794105 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248447.5 → XP_006248509.1  palmitoyltransferase ZDHHC19 isoform X1

    Conserved Domains (1) summary
    pfam01529
    Location:110 → 228
    zf-DHHC; DHHC palmitoyltransferase

  2. XM_063270376.1 → XP_063126446.1  palmitoyltransferase ZDHHC19 isoform X4

    UniProtKB/TrEMBL
    A6IRQ7

  3. XM_039088117.2 → XP_038944045.1  palmitoyltransferase ZDHHC19 isoform X4

    UniProtKB/TrEMBL
    A6IRQ7

  4. XM_039088116.2 → XP_038944044.1  palmitoyltransferase ZDHHC19 isoform X2

    Conserved Domains (1) summary
    pfam01529
    Location:112 → 230
    DHHC; DHHC palmitoyltransferase

  5. XM_063270375.1 → XP_063126445.1  palmitoyltransferase ZDHHC19 isoform X3

RNA

  1. XR_005491000.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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