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Spice1 spindle and centriole associated protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288111, updated on 4-Jan-2025

Summary

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Official Symbol
Spice1provided by RGD
Official Full Name
spindle and centriole associated protein 1provided by RGD
Primary source
RGD:1310729
See related
EnsemblRapid:ENSRNOG00000039024 AllianceGenome:RGD:1310729
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ccdc52; RGD1310729
Summary
Predicted to be involved in metaphase chromosome alignment; mitotic spindle assembly; and regulation of centriole replication. Predicted to be located in cytoplasm. Predicted to be active in centriole; centrosome; and spindle. Orthologous to human SPICE1 (spindle and centriole associated protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 26.8), Lung (RPKM 23.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Spice1 in Genome Data Viewer
Location:
11q21
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (69796490..69838304, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (56289291..56332382, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (61250649..61294116, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 44 Neighboring gene uncharacterized LOC120095657 Neighboring gene uncharacterized LOC134481069 Neighboring gene SID1 transmembrane family, member 1 Neighboring gene U2 spliceosomal RNA Neighboring gene upstream transcription factor family member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. SPICE--a previously uncharacterized protein required for centriole duplication and mitotic chromosome congression. Archinti M, et al. J Cell Sci, 2010 Sep 15. PMID 20736305
  2. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC95293

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in metaphase chromosome alignment IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic spindle assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of centriole replication ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in centriole ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  
located_in spindle ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
spindle and centriole-associated protein 1
Names
coiled-coil domain containing 52
coiled-coil domain-containing protein 52

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008285.1 → NP_001008286.1  spindle and centriole-associated protein 1

    See identical proteins and their annotated locations for NP_001008286.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085954
    UniProtKB/Swiss-Prot
    Q5RKG1
    UniProtKB/TrEMBL
    A0A0G2JX08
    Related
    ENSRNOP00000070088.2, ENSRNOT00000086286.3
    Conserved Domains (1) summary
    pfam15678
    Location:33 → 434
    SPICE; Centriole duplication and mitotic chromosome congression

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    69796490..69838304 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008768719.4 → XP_008766941.1  spindle and centriole-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JX08
    Related
    ENSRNOP00000061013.2, ENSRNOT00000064385.3
    Conserved Domains (1) summary
    pfam15678
    Location:33 → 434
    SPICE; Centriole duplication and mitotic chromosome congression

  2. XM_063270392.1 → XP_063126462.1  spindle and centriole-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JX08

  3. XM_063270391.1 → XP_063126461.1  spindle and centriole-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5RKG1
    UniProtKB/TrEMBL
    A0A0G2JX08

  4. XM_006248332.5 → XP_006248394.1  spindle and centriole-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006248394.1

    UniProtKB/Swiss-Prot
    Q5RKG1
    UniProtKB/TrEMBL
    A0A0G2JX08
    Conserved Domains (1) summary
    pfam15678
    Location:33 → 434
    SPICE; Centriole duplication and mitotic chromosome congression

  5. XM_006248334.4 → XP_006248396.1  spindle and centriole-associated protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006248396.1

    UniProtKB/TrEMBL
    A0A8I5ZMT5
    Related
    ENSRNOP00000079136.1, ENSRNOT00000098299.2
    Conserved Domains (1) summary
    pfam15678
    Location:1 → 381
    SPICE; Centriole duplication and mitotic chromosome congression

RNA

  1. XR_005491006.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5RKG1.1 GenPept UniProtKB/Swiss-Prot:Q5RKG1

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