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Nsun5 NOP2/Sun RNA methyltransferase 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288595, updated on 27-Nov-2024

Summary

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Official Symbol
Nsun5provided by RGD
Official Full Name
NOP2/Sun RNA methyltransferase 5provided by RGD
Primary source
RGD:1309268
See related
EnsemblRapid:ENSRNOG00000001450 AllianceGenome:RGD:1309268
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309268
Summary
Predicted to enable rRNA (cytosine-C5-)-methyltransferase activity. Predicted to be involved in several processes, including central nervous system development; rRNA base methylation; and regulation of myelination. Predicted to be located in nucleoplasm. Predicted to be active in nucleolus. Orthologous to several human genes including NSUN5 (NOP2/Sun RNA methyltransferase 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 78.8), Spleen (RPKM 71.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nsun5 in Genome Data Viewer
Location:
12q12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (26930204..26935887, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (21293637..21299319, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (24341940..24346900, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481281 Neighboring gene uncharacterized LOC120095917 Neighboring gene POM121 transmembrane nucleoporin Neighboring gene tripartite motif-containing 50 Neighboring gene FKBP prolyl isomerase family member 6 Neighboring gene uncharacterized LOC120095916

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program. Janin M, et al. Acta Neuropathol, 2019 Dec. PMID 31428936, Free PMC Article
  2. Loss of the ribosomal RNA methyltransferase NSUN5 impairs global protein synthesis and normal growth. Heissenberger C, et al. Nucleic Acids Res, 2019 Dec 16. PMID 31722427, Free PMC Article
  3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables rRNA (cytosine-C5-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cerebral cortex development ISO
Inferred from Sequence Orthology
more info
  
involved_in cognition ISO
Inferred from Sequence Orthology
more info
  
involved_in corpus callosum development ISO
Inferred from Sequence Orthology
more info
  
involved_in oligodendrocyte development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA base methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA base methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of myelination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
28S rRNA (cytosine-C(5))-methyltransferase
Names
NOL1/NOP2/Sun domain family, member 5
NOP2/Sun RNA methyltransferase family member 5
NOP2/Sun domain family, member 5
probable 28S rRNA (cytosine-C(5))-methyltransferase
putative methyltransferase NSUN5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191593.1 → NP_001178522.1  28S rRNA (cytosine-C(5))-methyltransferase

    See identical proteins and their annotated locations for NP_001178522.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A6J0D2, G3V660
    Related
    ENSRNOP00000001970.4, ENSRNOT00000001970.9
    Conserved Domains (2) summary
    TIGR00446
    Location:136 → 422
    nop2p; NOL1/NOP2/sun family putative RNA methylase
    cl17173
    Location:217 → 420
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    26930204..26935887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089215.2 → XP_038945143.1  28S rRNA (cytosine-C(5))-methyltransferase isoform X3

    Conserved Domains (1) summary
    COG0144
    Location:45 → 422
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

  2. XM_063271152.1 → XP_063127222.1  28S rRNA (cytosine-C(5))-methyltransferase isoform X1

  3. XM_063271153.1 → XP_063127223.1  28S rRNA (cytosine-C(5))-methyltransferase isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Chemical Information
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