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Rita1 RBPJ interacting and tubulin associated 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288683, updated on 27-Nov-2024

Summary

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Official Symbol
Rita1provided by RGD
Official Full Name
RBPJ interacting and tubulin associated 1provided by RGD
Primary source
RGD:1306772
See related
EnsemblRapid:ENSRNOG00000037720 AllianceGenome:RGD:1306772
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rita; RGD1306772
Summary
Predicted to enable tubulin binding activity. Predicted to be involved in negative regulation of Notch signaling pathway; neurogenesis; and nuclear export. Predicted to be located in centrosome and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human RITA1 (RBPJ interacting and tubulin associated 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 83.4), Muscle (RPKM 71.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rita1 in Genome Data Viewer
Location:
12q16
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (41610713..41614545)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (35950090..35953960)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (41484970..41488889)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit A1, pseudogene 2 Neighboring gene cilia and flagella associated protein 73 Neighboring gene DEAD-box helicase 54 Neighboring gene IQ motif containing D Neighboring gene uncharacterized LOC120095848 Neighboring gene two pore segment channel 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J. Wacker SA, et al. EMBO J, 2011 Jan 5. PMID 21102556, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neurogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nuclear export IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear export ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
RBPJ-interacting and tubulin-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044226.1 → NP_001037691.1  RBPJ-interacting and tubulin-associated protein 1

    See identical proteins and their annotated locations for NP_001037691.1

    Status: PROVISIONAL

    Source sequence(s)
    BC112384
    UniProtKB/Swiss-Prot
    Q2KJ10
    UniProtKB/TrEMBL
    A6J1I6
    Related
    ENSRNOP00000054067.2, ENSRNOT00000057242.4
    Conserved Domains (1) summary
    pfam17066
    Location:1 → 258
    RITA; RBPJ-interacting and tubulin associated protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    41610713..41614545
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249383.5 → XP_006249445.1  RBPJ-interacting and tubulin-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006249445.1

    UniProtKB/Swiss-Prot
    Q2KJ10
    UniProtKB/TrEMBL
    A6J1I6
    Conserved Domains (1) summary
    pfam17066
    Location:1 → 258
    RITA; RBPJ-interacting and tubulin associated protein

  2. XM_006249384.5 → XP_006249446.1  RBPJ-interacting and tubulin-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006249446.1

    UniProtKB/Swiss-Prot
    Q2KJ10
    UniProtKB/TrEMBL
    A6J1I6
    Conserved Domains (1) summary
    pfam17066
    Location:1 → 258
    RITA; RBPJ-interacting and tubulin associated protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2KJ10.1 GenPept UniProtKB/Swiss-Prot:Q2KJ10

Gene LinkOut

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